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Aluminum Fluoride-18 Labeled Mannosylated Dextran: Radiosynthesis and Initial Preclinical Positron Emission Tomography Studies
PurposeIn addition to being expressed on liver sinusoidal endothelial cells, mannose receptors are also found on antigen-presenting cells, including...
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Global untargeted and individual targeted plasma metabolomics of breast cancer recurrence modified by hormone receptors
BackgroundBreast cancer is a heterogeneous and complex etiological disease. Understanding perturbations of circulating metabolites could improve...
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The homozygous pathogenic variant of the POMGNT1 gene identified using whole-exome sequencing in Iranian family with congenital hydrocephalus
BackgroundHydrocephalus is one of the most common pathophysiological disabilities with a high mortality rate, which occurs both congenitally and...
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Screening of antigenic epitopes related to the adhesion of the avian Escherichia coli Type 1 Fimbrial Agglutinin Domain
BackgroundAvian Escherichia coli ( E.coli ) type 1 fimbriae adhere to avian tracheal epithelial cells through the FimH protein. However, the...
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Anti-melanogenesis effect from Wampee fruit pectin via α-MSH/TRY pathway in A375 cells
BackgroundPolysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and...
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C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens
Purpose of ReviewAllergic diseases represent a major health problem of increasing prevalence worldwide. In allergy, dendritic cells (DCs) contribute...
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The role of antibody glycosylation in autoimmune and alloimmune kidney diseases
Immunoglobulin glycosylation is a pivotal mechanism that drives the diversification of antibody functions. The composition of the IgG glycome is...
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Potential of methacrylated acemannan for exerting antioxidant-, cell proliferation-, and cell migration-inducing activities in vitro
BackgroundAcemannan is an acetylated polysaccharide of Aloe vera extract with antimicrobial, antitumor, antiviral, and antioxidant activities. This...
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Glycobiology of rheumatic diseases
Glycosylation has a profound influence on protein activity and cell biology through a variety of mechanisms, such as protein stability, receptor...
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Molecular environment and atypical function: What do we know about enzymes associated with Mucopolysaccharidoses?
Mucopolysaccharidoses are a group of lysosomal storage disorders caused by deficiency of enzymes involved in glycosaminoglycans degradation....
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Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging
Myxoid liposarcoma (MLS) is the second most common subtype of liposarcoma, accounting for ~6% of all sarcomas. MLS is characterized by a...
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Protein glycosylation in cardiovascular health and disease
Protein glycosylation, which involves the attachment of carbohydrates to proteins, is one of the most abundant protein co-translational and...
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Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study
BackgroundLow endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART)....
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Characterization of a novel polysaccharide from red ginseng and its ameliorative effect on oxidative stress injury in myocardial ischemia
BackgroundRed ginseng (RG) was widely used as traditional Chinese medicine (TCM) or dietary supplement. However, few researches had been reported on...
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Decoding the glycoproteome: a new frontier for biomarker discovery in cancer
Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting...
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N-Glycan profiling of lung adenocarcinoma in patients at different stages of disease
Lung adenocarcinoma (LAC) is the most common form of lung cancer that increases in non-smokers at younger age. Altered protein glycosylation is one...
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Allelic functional variation of FimH among Salmonella enterica subspecies
Salmonella enterica has a wide diversity, with numerous serovars belonging to six different subspecies with dynamic animal-host tropism. The FimH...
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Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and a frequent cause of kidney failure. Currently, the...
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Glycosylation and behavioral symptoms in neurological disorders
Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is a complex post-translational modification that...
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Harnessing Plant Flavonoids to Fight Pancreatic Cancer
Purpose of ReviewThis review draws on the last fifteen years (2009–2024) of published data to summarize the potential effect of plant flavonoids on...
