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Genotoxic effect of Tamiflu and Adamine on DNA content in male albino mice
BackgroundTamiflu (Oseltamivir) and Adamine (Amantadine HCl) are antiviral drugs which are used for prevention and treatment for influenza. The...
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Blood metal levels linked with hematological, oxidative, and hepatic-renal function disruption in Swiss albino mice exposed to multi-metal mixture
This study evaluates the toxic effect of various doses of multi-metal mixtures leading to metal accumulation in the blood of exposed mice and...
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Anticancer potential of Chenopodium album leaf extract against Ehrlich ascites carcinoma cells in Swiss albino mice
BackgroundChenopodium album (Family: Amaranthaceae) is a nutritive herb mainly found in Bangladesh and had reported that it is having different...
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Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model
PurposeCrime-related spiking of alcoholic drinks with prescription drugs is quite common and has been happening for centuries. This study, therefore,...
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Vitamin B12 and coenzyme Q10 ameliorated alcohol-driven impairment of hematological parameters, inflammation, and organ damage in a mouse model
IntroductionChronic alcohol consumption is associated with a myriad of negative physiological and biochemical changes in humans. Vitamin B12 and...
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Screening assessment of trimethoxy flavonoid and - (-)-epigallocatechin-3-gallate against formalin-induced arthritis in Swiss albino rats and binding properties on NF-κB-MMP9 proteins
BackgroundThe isolated trimethoxy flavonoid 4a,5,8,8a-tetrahydro-5-hydroxy-3,7,8-trimethoxy-2-(3,4-dimethoxyphenyl) chromen-4-one (TMF) from...
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Characterization of pharmacological properties of methanolic seed and stem bark extracts of Ziziphus mauritiana (BAU Kul) using in-vitro and in-vivo animal (Swiss albino male mice) model
BackgroundZiziphus mauritiana belongs to family of Rhamnaceae, is an improved fast-growing variety of plum and seasonal fruit which is very popular...
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Toxic effects of AB-CHMINACA on liver and kidney and detection of its blood level in adult male mice
BackgroundAB-CHMINACA is a cannabimimetic indazole derivative. In 2013, it was reported in different countries as a substance of abuse.
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Effects of Tamiflu and Adamine on histology and ultrastructure of the liver of albino mice
BackgroundTamiflu (Oseltamivir) and Adamine (Amantadine HCl) are antiviral drugs which are used for prevention and treatment for influenza. The...
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Ascorbic acid interaction with phytol: a modulatory effects on the anti-pyretic activity of paracetamol in Swiss albino mice
BackgroundAntioxidants have protective capacity, and can be used combinedly with other substances. Both, ascorbic acid (AA) and phytol (PHY) have...
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Kruppel-like factor 5 (Klf5) in fetal-maternal tissue during periimplantation and effects of ovarian steroid hormone antagonist on its expression during uterine receptivity of albino mice
BackgroundEmbryo implantation is a tightly regulated sequence of events regulated by ovarian steroids, estrogen and progesterone, and their...
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Isorhamnetin exerts anti-tumor activity in DEN + CCl4-induced HCC mice
BackgroundHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer and the main cause of cancer death globally. The use of medicinal...
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Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer
The glutamine synthetase (GS) facilitates cancer cell growth by catalyzing de novo glutamine synthesis. This enzyme removes ammonia waste from the...
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Differential effect of visfatin inhibition on the testicular androgen and estrogen receptors expression in early pubertal mice
BackgroundIt is now well known that visfatin is expressed in the testis and ovary of various animals. Visfatin is known to regulate gonadal functions...
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Comparative evaluation of silver nanoparticles and human platelet rich-plasma versus traditional therapy in the treatment of murine chronic toxoplasmosis
Toxoplasmosis is a worldwide parasitic disease infecting about one-third of the human population. At present, licensed medications are incapable of...
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Haploid Parthenogenetic Embryos Exhibit Unique Stress Response to pH, Osmotic and Oxidative Stress
Preimplantation-stage embryos are susceptible to various types of stress when cultured in vitro. Parthenogenetic embryos that lack spermatozoa...
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Eugenol: effective complementary treatment for cryptosporidiosis in experimentally infected mice
Cryptosporidiosis is an opportunistic, globally distributed parasitic disease. Whereas Cryptosporidium causes asymptomatic infection and diarrhea in...
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Evaluation of the prophylactic and therapeutic efficacies of mucus and tissue nucleoproteins extracted from Biomphalaria alexandrina snails on schistosomiasis mansoni
Schistosomiasis is a neglected tropical disease with considerable morbidity. The lone effective drug, praziquantel (PZQ), is showing emergence of...
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Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies
Hepatocellular carcinoma (HCC) is commonly associated with disturbances in glucose metabolism and enhanced glycolysis. However, a controversial role...
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Phyto-therapeutic potential of stem bark of the wonder tree, Prosopis cineraria (L.) Druce in LPS-induced mouse model: An Anti-Inflammatory Study
BackgroundTherapeutic potential of Prosopis cineraria has been extensively explored by many eminent researchers against various serious diseases but...
