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Major depressive disorder
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of interest or pleasure in previously enjoyable activities,...
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Metabolic features of treatment-refractory major depressive disorder with suicidal ideation
Peripheral blood metabolomics was used to gain chemical insight into the biology of treatment-refractory Major Depressive Disorder with suicidal...
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Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder
The molecular events underlying the development, manifestation, and course of schizophrenia, bipolar disorder, and major depressive disorder span...
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Major depressive disorder: hypothesis, mechanism, prevention and treatment
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, the...
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Identifying plasma metabolic characteristics of major depressive disorder, bipolar disorder, and schizophrenia in adolescents
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the...
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The metabolome-wide signature of major depressive disorder
Major Depressive Disorder (MDD) is a common, frequently chronic condition characterized by substantial molecular alterations and pathway...
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Treatment Patterns During Major Depressive Episodes Among Patients with Major Depressive Disorder: A Retrospective Database Analysis
BackgroundMajor depressive disorder, a highly prevalent mental health condition, can be challenging to treat.
ObjectiveWe aimed to characterize...
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Deep brain stimulation for refractory major depressive disorder: a comprehensive review
Deep brain stimulation (DBS) has emerged as a promising treatment for select patients with refractory major depressive disorder (MDD). The clinical...
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Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder
Bipolar disorder (BD) features heterogenous clinical presentation and course of illness. It remains unclear how subphenotypes associate with genetic...
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Role of trazodone in treatment of major depressive disorder: an update
Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. Trazodone, a triazolopyridine serotonin...
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Clinical distinctions in symptomatology and psychiatric comorbidities between misdiagnosed bipolar I and bipolar II disorder versus major depressive disorder
BackgroundTo explore the demographic and clinical features of current depressive episode that discriminate patients diagnosed with major depressive...
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Pharmacogenomic Testing to Guide Treatment of Major Depressive Disorder: A Systematic Review
Purpose of reviewMajor depressive disorder is a prevalent psychiatric illness associated with significant morbidity, mortality, and economic burden...
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The genetic basis of major depressive disorder
The genetic dissection of major depressive disorder (MDD) ranks as one of the success stories of psychiatric genetics, with genome-wide association...
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Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study
BackgroundDistorted thoughts are common in Major Depressive Disorder (MDD), and can impact patients’ perceptions of depression severity, and predict...
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Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families
Psychotic and affective disorders often aggregate in the relatives of probands with schizophrenia, and genetic studies show substantial genetic...
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Diagnostic conversion to bipolar disorder among adolescents and young adults with major depressive disorder: a nationwide longitudinal study
Although several studies have examined a diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BD), only a few studies...
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Aberrant resting-state co-activation network dynamics in major depressive disorder
Major depressive disorder (MDD) is a globally prevalent and highly disabling disease characterized by dysfunction of large-scale brain networks....
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Technical and clinical considerations for electroencephalography-based biomarkers for major depressive disorder
Major depressive disorder (MDD) is a prevalent and debilitating psychiatric disease that leads to substantial loss of quality of life. There has been...
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Retinoid homeostasis in major depressive disorder
The small, hormone-like molecule retinoic acid (RA) is a vital regulator in several neurobiological processes that are affected in depression. Next...
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Pathway from childhood trauma to nonsuicidal self-injury in adolescents with major depressive disorder: the chain-mediated role of psychological resilience and depressive severity
This study aimed to explore the pathway from childhood trauma to nonsuicidal self-injury (NSSI) in adolescents with major depressive disorder (MDD)...
