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Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review
Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as...
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Impact of Bariatric Surgery in Reducing Macrovascular Complications in Severely Obese T2DM Patients
BackgroundEvidence from real-world studies have suggested a reduced rate of macrovascular complications following bariatric surgery. We undertook...
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Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study
BackgroundPatients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI) who receive systemic chemotherapy have a poor prognosis. This...
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More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study
Adjustment for prognostic covariates increases the statistical power of randomized trials. The factors influencing the increase of power are...
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BMI and BMI change following incident type 2 diabetes and risk of microvascular and macrovascular complications: the EPIC-Potsdam study
Aims/hypothesisStudies suggest decreased mortality risk among people who are overweight or obese compared with individuals with normal weight in type...
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Efficacy and safety of immune checkpoint inhibitors for hepatocellular carcinoma patients with macrovascular invasion or extrahepatic spread: a systematic review and meta-analysis of 54 studies with 6187 hepatocellular carcinoma patients
Background and aimsThe impacts of macrovascular invasion (MVI) or extrahepatic spread (EHS) on the efficacy and safety of immune checkpoint...
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Impact of bariatric surgery on the development of diabetic microvascular and macrovascular complications
BackgroundWhile bariatric surgery has been shown to improve type 2 diabetes (DM) control in the obese population, the effect on long-term DM...
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Importance of hematological parameters for micro- and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
BackgroundThe prognostic importance of several hematological parameters has been scarcely investigated in type 2 diabetes. So, we aimed to evaluate...
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A Review of the Current Evidence: Impact of Metabolic Surgery on Diabetes Outcomes and Obesity-Associated Macrovascular Complications
Purpose of ReviewType 2 diabetes (T2D) and obesity are comorbidities that generally progress with time even when non-invasive therapies are...
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Macrovascular Risk Equations Based on the CANVAS Program
BackgroundWidely used risk equations for cardiovascular outcomes for individuals with type 2 diabetes mellitus (T2DM) have been incapable of...
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Real-world outcome of immune checkpoint inhibitors for advanced hepatocellular carcinoma with macrovascular tumor thrombosis
Programmed cell death protein-1 (PD-1) inhibitors have shown promising results for treating advanced hepatocellular carcinoma (HCC). However, the...
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Continuous glucose monitoring data for artificial intelligence-based predictive glycemic event: A potential aspect for diabetic care
BackgroundDiabetes mellitus is a chronic metabolic disorder that affects 537 million of the population worldwide whereby continuous glucose...
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A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease
A higher resting heart rate (RHR) is associated with an increased risk of cardiovascular events in patients with type 2 diabetes mellitus (T2DM) and...
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Digital gangrene in systemic sclerosis patients: not only due to the microvascular disease
ObjectiveThis study aims to investigate the characteristics, risk factors, and outcomes of digital gangrenes in SSc patients, and to identify whether...
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Assessment HOMA as a predictor for new onset diabetes mellitus and diabetic complications in non-diabetic adults: a KoGES prospective cohort study
BackgroundHomeostasis model assessment for insulin resistance (HOMA-IR) is a biomarker for type 2 diabetes mellitus (T2DM). However, the role of...
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Mannose-binding lectin does not explain the dismal prognosis after an acute coronary event in dysglycaemic patients. A report from the GAMI cohort
BackgroundMannose binding lectin (MBL) has been suggested to be associated with an impaired cardiovascular prognosis in dysglycaemic conditions, but...
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Efficacy of Αtezolizumab–Βevacizumab in BCLC-C cirrhotic patients with hepatocellular carcinoma according to the type of disease progression, the type of BCLC-C and liver disease severity
PurposeThe aim of our study was to evaluate, under real-life conditions, survival of patients with advanced HCC (BCLC-C), either initially presenting...
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Sedation versus general anesthesia on all-cause mortality in patients undergoing percutaneous procedures: a systematic review and meta-analysis
BackgroundThe comparison between sedation and general anesthesia (GA) in terms of all-cause mortality remains a subject of ongoing debate. The...
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Clinical outcomes by atherosclerotic cardiovascular disease risk score and blood pressure level in high risk individuals with type 2 diabetes
Clinical practice guidelines for patients with diabetes recommend using blood pressure (BP) and atherosclerotic cardiovascular disease (ASCVD) risk...
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Development and Internal Validation of a Discrete Event Simulation Model of Diabetic Kidney Disease Using CREDENCE Trial Data
IntroductionThe Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study showed that compared...
