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Analysis of gasoline-related pollutant exposures and risks in California between 1996 and 2014
BackgroundGasoline-powered vehicles and equipment are an important source of air pollution in California. Many gasoline-related pollutants pose...
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Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography
BackgroundThe present work is aimed at quantification of organic volatile solvents like Methanol, Ethanol, Acetonitrile, Isopropyl alcohol (IPA),...
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Inflammation and the pathological progression of Alzheimer’s disease are associated with low circulating choline levels
Deficiency of dietary choline, an essential nutrient, is observed worldwide, with ~ 90% of Americans being deficient. Previous work highlights a...
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Toxizität von Methyl-tert-butylether auf innere Organe von Versuchstieren unter Kältebedingungen
BackgroundThe use of methyl tert-butyl ether (MTBE) is frequent. It can produce pollution of the environment and is a stress factor with potential...
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Social determination of alcohol consumption among Indigenous peoples in Colombia: a qualitative meta-synthesis
BackgroundAlcohol consumption is a social phenomenon that involves society, groups, and individuals from different cultures around the world. Among...
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Qualitative Distribution of Endogenous Cholesteryl Esters in Plasma of Humans and Three Rodent Species Using Stepwise UPLC-Q-Exactive-MS
ObjectiveCholesteryl esters (CEs) are composed of various fatty acyl chains attached to the hydroxyl groups of cholesterol, and abnormalities in...
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Alpha-methyltryptamine and 5-(2-methylaminopropyl)-benzofuran (5-MAPB) fatal co-intoxication: case report and review of literature
The scientific literature contains little reliable data regarding new psychoactive substances and designer drugs, making it difficult to assess toxic...
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Coenzyme Q deficiency may predispose to sudden unexplained death via an increased risk of cardiac arrhythmia
Cardiac arrhythmia is currently considered to be the direct cause of death in a majority of sudden unexplained death (SUD) cases, yet the genetic...
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Seminal plasma metabolomics and lipidomics profiling to identify signatures of pituitary stalk interruption syndrome
BackgroundPituitary stalk interruption syndrome (PSIS) is a rare disease caused by congenital pituitary anatomical defects. The underlying mechanisms...
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Effect of PFOA exposure on diminished ovarian reserve and its metabolism
Owing to its difficulty in degrading and ease of accumulation in the body, perfluorooctanoic acid (PFOA) has a detrimental effect on reproduction....
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Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure
Electronic cigarette (Ecig) use has become more common, gaining increasing acceptance as a safer alternative to tobacco smoking. However, the 2019...
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Sex and disease severity-based analysis of steroid hormones in ME/CFS
PurposeMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by persistent fatigue and decreased daily...
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Aqueous extract of Platycodon grandiflorus attenuates lipopolysaccharide-induced apoptosis and inflammatory cell infiltration in mouse lungs by inhibiting PI3K/Akt signaling
BackgroundAcute lung injury (ALI), an acute inflammatory lung disease, can cause a rapid inflammatory response in clinic, which endangers the...
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Advances in Analyzing the Breast Cancer Lipidome and Its Relevance to Disease Progression and Treatment
Abnormal lipid metabolism is common in breast cancer with the three main subtypes, hormone receptor (HR) positive, human epidermal growth factor 2...
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High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth
BackgroundAlthough cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for...
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An assessment of solvent residue contaminants related to cannabis-based products in the South African market
Organic solvents are used for manufacturing herbal medicines and can be detected as residues of such processing in the final products. It is...
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Changes of Facial Lipidomics by Intense Pulsed Light Treatment Based on LC-MS
BackgroundIntense pulsed light (IPL) has been widely used to improve cutaneous photoaging in recent years. Several studies began to explore the...
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Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice
Apolipoprotein E ε4 ( APOE4 ) is the primary genetic risk factor for the late-onset form of Alzheimer’s disease (AD). Although the reason for this...
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A metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic...
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Lipidomics analysis of human follicular fluid form normal-weight patients with polycystic ovary syndrome: a pilot study
BackgroundThe polycystic ovary syndrome (PCOS) is the most common endocrine associated with insulin resistance, even in the absence of overweight....
