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Transcriptomic profiles reveal the characteristics of oocytes and cumulus cells at GV, MI, and MII in follicles before ovulation
BackgroundThe oocyte and its surrounding cumulus cells (CCs) exist as an inseparable entity. The maturation of the oocyte relies on communication...
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Exploring gonadotropin dosing effects on MII oocyte retrieval in ovarian stimulation
PurposeOvarian stimulation with gonadotropins is crucial for obtaining mature oocytes for in vitro fertilization (IVF). Determining the optimal...
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Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes
PurposeDetermine if the gene expression profiles of ovarian support cells (OSCs) and cumulus-free oocytes are bidirectionally influenced by...
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Dynamic methylation pattern of H19DMR and KvDMR1 in bovine oocytes and preimplantation embryos
PurposeThis study aimed to evaluate the epigenetic reprogramming of ICR1 (KvDMR1) and ICR2 (H19DMR) and expression of genes controlled by them as...
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Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM
BackgroundThe suggested effects of the oocyte secreted GDF9 and BMP15 growth factors on oocyte maturation are currently based on recombinant...
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In vitro matured oocytes have a higher developmental potential than in vivo matured oocytes after hormonal ovarian stimulation in Callithrix jacchus
BackgroundThe common marmoset, Callithrix jacchus , is an invaluable model in biomedical research. Its use includes genetic engineering applications,...
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Influx of zwitterionic buffer after intracytoplasmic sperm injection (ICSI) membrane piercing alters the transcriptome of human oocytes
Purpose/study questionDoes piercing oocyte membranes during ICSI allow the influx of surrounding zwitterionic buffer into human oocytes and result in...
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Use of confocal microscopy and intracytoplasmic sperm injection (ICSI) to assess viability of equine oocytes from young and old mares after vitrification
BackgroundThe impact of vitrification on oocyte developmental competence as a function of donor age remains an important issue in assisted...
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Association between oocyte retrieval technique and number of oocytes retrieved
PurposeTo assess if there is an optimal oocyte retrieval (OR) technique to retrieve a maximum number of oocytes and mature oocytes (MII).
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Fructose improves titanium dioxide nanoparticles induced alterations in developmental competence of mouse oocytes
AimsWe investigated the effects of intraperitoneal injections of titanium dioxide nanoparticles (TiO 2 NPs, 100 mg/kg) for 5 consecutive days on the...
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NET1 is a critical regulator of spindle assembly and actin dynamics in mouse oocytes
BackgroundNeuroepithelial transforming gene 1 (NET1) is a RhoA subfamily guanine nucleotide exchange factor that governs a wide array of biological...
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Oocyte diameter predicts the maturation rate of human immature oocytes collected ex vivo
PurposeTo study the impact of oocyte diameter and cumulus cell mass on the potential for final maturation of immature human oocytes in vitro.
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Focusing on the accumulation of chromatin/chromosomes around nucleoli and optimizing the timing of ICSI to facilitate the rescue in vitro maturation of denuded GV stage oocytes
PurposeThis study aims to achieve the methodological improvement of rescue IVM by predicting germinal vesicle breakdown (GVBD) and optimizing the...
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High expression of CFTR in cumulus cells from mature oocytes is associated with high-quality of oocyte and subsequent embryonic development
ObjectiveThe purpose of this study was to explore the association of expression of cystic fibrosis transmembrane conductance regulator (CFTR) in...
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Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes
BackgroundHigh-temperature requirement protease A2 (HtrA2/Omi) is a mitochondrial chaperone that is highly conserved from bacteria to humans. It...
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Proteomic analysis implicates that postovulatory aging leads to aberrant gene expression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes
BackgroundIn mammals, oocytes display compromised quality after experiencing a process of postovulatory aging. However, the mechanisms underlying are...
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Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B
The subcortical maternal complex (SCMC) is a multiprotein complex in oocytes and preimplantation embryos that is encoded by maternal effect genes....
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Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Improved The Aged Mouse IVM Oocytes Quality
During assisted reproductive technology (ART) treatment, the aged women, especially those over 35 years old, have fewer mature oocytes and poorer...
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Human metaphase II oocytes with narrow perivitelline space have poor fertilization, developmental, and pregnancy potentials
PurposeTo analyze the fertilization, developmental, and pregnancy potentials in oocytes with narrow perivitelline space.
MethodsPerivitelline space...
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Comparison of miRNA landscapes between the human oocytes with or without arrested development
PurposeBy exploring the role of miRNAs in human oocyte development, the study was conducted to investigate the epigenetic mechanism contributing to...
