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The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway
BackgroundAdenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. Moreover, the unique biological characteristics...
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Protective role of FBXL19 in Streptococcus pneumoniae-induced lung injury in pneumonia immature mice
ObjectiveStreptococcus pneumoniae ( Spn ) is a common pathogen for pediatric pneumonia and leads to severe lung injury. This study is conducted to...
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The function role of ubiquitin proteasome pathway in the ER stress-induced AECII apoptosis during hyperoxia exposure
BackgroundBronchopulmonary dysplasia (BPD) is a major cause of mortality and morbidity in premature infants, characterized by alveolar dysplasia and...
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UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma
Cellular heterogeneity in cancer is linked to disease progression and therapy response, although mechanisms regulating distinct cellular states...
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A novel autism-associated UBLCP1 mutation impacts proteasome regulation/activity
The landscape of autism spectrum disorder (ASD) in Lebanon is unique because of high rates of consanguinity, shared ancestry, and increased remote...
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TRIM4-mediated ubiquitination of NSP2 restricts porcine reproductive and respiratory syndrome virus proliferation
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and virulent infectious disease caused by the porcine reproductive and...
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LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma
PurposeThere is compelling evidence that long-stranded non-coding RNAs (lncRNAs) play an important role in the progression of hepatocellular...
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Combined time-restricted feeding and cisplatin enhance the anti-tumor effects in cisplatin-resistant and -sensitive lung cancer cells
Combination therapy as an important treatment option for lung cancer has been attracting attention due to the primary and acquired resistance of...
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Proteasome inhibitors attenuates mitoxantrone-triggered immunogenic cell death in prostate cancer cells
Both mitoxantrone (MTX) and proteasome inhibitors efficiently trigger immunogenic cell death (ICD) in cancer cells. However, whether the combination...
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LncRNA HOXC-AS3 accelerates malignant proliferation of cervical cancer cells via stabilizing KDM5B
BackgroundCervical cancer (CC) is a common malignancy amongst women globally. Ubiquitination plays a dual role in the occurrence and development of...
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A relatively low glucose promotes the proliferation of vascular endothelial cells by suppressing VEGFR2 O-GlcNAcylation and its proteasome degradation
PurposeVascular endothelial growth factor receptors (VEGFRs) have been demonstrated to play a critical role in ischemic retinal diseases, as VEGFRs...
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Heme-regulated inhibitor: an overlooked eIF2α kinase in cancer investigations
Heme-regulated inhibitor (HRI) kinase is a serine–threonine kinase, controlling the initiation of protein synthesis via phosphorylating α subunit of...
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Interferon-γ-induced GBP1 is an inhibitor of human papillomavirus 18
BackgroundHuman papillomavirus (HPV) infection is an important factor leading to cervical cell abnormalities. 90% of cervical cancers are closely...
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Disruption of asparagine-linked glycosylation to rescue and alter gating of the NaV1.5-Na+ channel
SCN5A gene encodes the voltage-gated sodium channel Na V 1.5 which is composed of a pore-forming α subunit of the channel. Asparagine (N)-linked...
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GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer
Receptor-interacting protein kinase 4 (RIPK4) is increasingly recognized as a pivotal player in ovarian cancer, promoting tumorigenesis and disease...
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CRL2KLHDC3 and CRL1Fbxw7 cooperatively mediate c-Myc degradation
c-Myc is a proto-oncoprotein that regulates various cellular processes and whose abnormal expression leads to tumorigenesis. c-Myc protein stability...
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Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer
Despite epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have shown remarkable efficacy in patients with EGFR -mutant...
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Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC
Aberrant cell proliferation is a hallmark of cancer, including breast cancer. Here, we show that USP27X is required for cell proliferation and...
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Control of SOX2 protein stability and tumorigenic activity by E3 ligase CHIP in esophageal cancer cells
SOX2 is highly expressed and controls tumor initiation and cancer stem cell function in various squamous cell carcinomas including esophageal...
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PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effective controlled via selective...
