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Lysergic Acid Diethylamide (LSD) for the Treatment of Anxiety Disorders: Preclinical and Clinical Evidence
Anxiety disorders (ADs) represent the sixth leading cause of disability worldwide, resulting in a significant global economic burden. Over 50% of...
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The effects of Lysergic Acid Diethylamide (LSD) on the Positive Valence Systems: A Research Domain Criteria (RDoC)-Informed Systematic Review
Background and ObjectivesThe renewed interest in psychedelic research provides growing evidence of potentially unique effects on various aspects of...
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The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity
Psychedelics have emerged as promising candidate treatments for various psychiatric conditions, and given their clinical potential, there is a need...
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Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants
Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects of these...
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Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects
Growing interest has been seen in using lysergic acid diethylamide (LSD) and psilocybin in psychiatric research and therapy. However, no modern...
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Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline
Lysergic acid diethylamide (LSD) is a serotonergic psychedelic compound receiving increasing interest due to putative anxiolytic and antidepressant...
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Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single,...
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Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects
Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric research and therapy. However, no modern studies have...
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Perceived risk of LSD varies with age and race: evidence from 2019 United States cross-sectional data
PurposePsychedelics are being explored for their potential therapeutic benefits across a wide range of psychiatric diagnoses and may usher in a new...
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Identification of 1-(thiophene-2-carbonyl)-LSD from blotter paper falsely labeled “1D-LSD”
PurposeSince the mid-2010s, lysergic acid diethylamide (LSD) analogs made for substance abuse have periodically emerged. In this case, three pieces...
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Early-onset alcohol, tobacco, and illicit drug use with age at onset of hypertension: a survival analysis
PurposeTo examine the associations of age when first substance use and early-onset substance use before age 18 with age at onset (AAO) of...
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Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine
Neural complexity correlates with one’s level of consciousness. During coma, anesthesia, and sleep, complexity is reduced. During altered states,...
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Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants
AbstractThere is renewed interest in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. Although acute subjective...
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Dose-response relationships of LSD-induced subjective experiences in humans
Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousness. Here...
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The Therapeutic Effects of Classic Psychedelics in Alcohol Use Disorder
Purpose of reviewThis article utilizes a pre-existing framework in the field of addiction to comprehensively capture the effects of classic...
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Identification of LSD analogs, 1cP-AL-LAD, 1cP-MIPLA, 1V-LSD and LSZ in sheet products
PurposeMany analogs of lysergic acid diethylamide (LSD) have recently appeared as designer drugs around the world. These compounds are mainly...
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High-sensitivity method for the determination of LSD and 2-oxo-3-hydroxy-LSD in oral fluid by liquid chromatography‒tandem mass spectrometry
PurposeWe have developed and validated a high-sensitivity method to quantify lysergic acid diethylamide (LSD) and 2-oxo-3-hydroxy-LSD (OH-LSD) in...
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Neurobiology of the Antidepressant Effects of Serotonergic Psychedelics: A Narrative Review
Purpose of ReviewSerotonergic psychedelics include psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine (DMT), and other agonists of the...
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LSD increases sleep duration the night after microdosing
Microdosing psychedelic drugs at a level below the threshold to induce hallucinations is an increasingly common lifestyle practice. However, the...
