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Typical carcinoid in right middle lobe of pulmonary hypoplasia
BackgroundPulmonary typical carcinoid occurring in hypoplasia of the right middle lobe is very rare.
Case presentationA routine examination's chest...
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Lung transplantation with concomitant cardiac repair for congenital hypoplasia of bilateral pulmonary arteries and patent ductus arteriosus
BackgroundProfound pulmonary arterial hypertension with end-stage right heart failure is considered to be the main cause of death in children with...
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Hydrops fetalis caused by a complex congenital heart defect with concurrent hypoplasia of pulmonary blood vessels and lungs visualized by micro-CT in a French Bulldog
BackgroundHydrops fetalis (HF) is fluid accumulation in fetus body cavities and subcutaneous tissue. The condition has been described in various...
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Congenital diaphragmatic hernia: phosphodiesterase-5 and Arginase inhibitors prevent pulmonary vascular hypoplasia in rat lungs
BackgroundSevere pulmonary hypoplasia related to congenital diaphragmatic hernia (CDH) continues to be a potentially fatal condition despite advanced...
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Critical functional lung volumes in neonatal intensive care: evidence and clinical applications
AbstractRespiratory disease is common in premature and sick newborn infants and can often necessitate the initiation of intensive care. Newborn...
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Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients
BackgroundCartilage-hair hypoplasia (CHH) is a rare syndromic immunodeficiency with metaphyseal chondrodysplasia and increased risk of malignancy. In...
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Beyond the diaphragm and the lung: a multisystem approach to understanding congenital diaphragmatic hernia
Congenital diaphragmatic hernia (CDH) is a birth defect characterized by the incomplete closure of the diaphragm and herniation of abdominal organs...
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Interstitial lung disease in the newborn
Although relatively rare, interstitial lung diseases may present with respiratory distress in the newborn period. Most commonly these include...
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The ten-year evaluation of clinical characteristics in congenital lung anomaly in pediatrics; a retrospective study in North of Iran
IntroductionCongenital lung anomalies (CLA) are a group of anomalies, including congenital cystic adenomatoid malformation (CCAM), bronchopulmonary...
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Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2
BackgroundClinical and experimental evidence shows lung fluid volume as a modulator of fetal lung growth with important value in treating fetal lung...
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Pulmonary hypoplasia correlates with the length of anhydramnios in patients with early pregnancy renal anhydramnios (EPRA)
BackgroundEarly pregnancy renal anhydramanios (EPRA) occurs when the fetus is anuric before 22 weeks gestational age (GA) and is considered...
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The effect of tracheal occlusion in congenital diaphragmatic hernia in the nitrofen rat lung explant model
PurposeHere, we establish a tracheal occlusion (TO) model with rat lung explants in nitrofen-induced pulmonary hypoplasia in the congenital...
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Fetal lung hypoxia and energetic cell failure in the nitrofen-induced congenital diaphragmatic hernia rat model
PurposeCongenital diaphragmatic hernia (CDH) pathogenesis is poorly understood. We hypothesize that fetal CDH lungs are chronically hypoxic because...
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Using MRI-derived observed-to-expected total fetal lung volume to predict lethality in fetal skeletal dysplasia
BackgroundPulmonary hypoplasia is the primary cause of perinatal death in lethal skeletal dysplasias. The antenatal ultrasound correlates for...
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Sustained inflation improves initial lung aeration in newborn rabbits with a diaphragmatic hernia
BackgroundInfants with a congenital diaphragmatic hernia (DH) have underdeveloped lungs and require mechanical ventilation after birth, but the...
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Congenital lung malformations
Congenital lung malformations (CLMs) are rare developmental anomalies of the lung, including congenital pulmonary airway malformations (CPAM),...
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Effects of systemic anticoagulation in a murine model of compensatory lung growth
BackgroundNeonates with congenital diaphragmatic hernia (CDH) suffer from pulmonary hypoplasia (PH) and may require extracorporeal membrane...
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A de novo variant in CASK gene causing intellectual disability and brain hypoplasia: a case report and literature review
BackgroundThe pathogenic variation of CASK gene can cause CASK related mental disorders. The main clinical manifestations are microcephaly with...
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Fetal MRI radiomics: non-invasive and reproducible quantification of human lung maturity
ObjectivesTo assess the reproducibility of radiomics features extracted from the develo** lung in repeated in-vivo fetal MRI acquisitions.
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