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Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction
BackgroundObesity has been identified as a risk factor for acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, the underlying...
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Blood MMP-9 measured at 2 years after lung transplantation as a prognostic biomarker of chronic lung allograft dysfunction
BackgroundLong-term outcomes of lung transplantation (LTx) remain hampered by chronic lung allograft dysfunction (CLAD). Matrix metalloproteinase 9...
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Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury
Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur...
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Esophageal Dysfunction in Post-lung Transplant: An Enigma
The prevalence of lung transplants has increased over the years, albeit with a low survival rate amongst all solid organ transplants, including liver...
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Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction
BackgroundParticulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various infectious...
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Early chest CT abnormalities to predict the subsequent occurrence of chronic lung allograft dysfunction
IntroductionChronic lung allograft dysfunction (CLAD) can take two forms: bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome...
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Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
BackgroundChronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective...
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Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL
ObjectivetRNA-derived small RNAs (tsRNAs) are novel non-coding RNAs with various functions in multiple cancers. Nevertheless, whether vitamin D...
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Long COVID symptoms after 8-month recovery: persistent static lung hyperinflation associated with small airway dysfunction
BackgroundLimited research has investigated the relationship between small airway dysfunction (SAD) and static lung hyperinflation (SLH) in patients...
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Pituitary-adrenal axis dysfunction induced by tislelizumab immunotherapy for non-small cell lung cancer: a case series and literature review
BackgroundAdverse events of secondary adrenal insufficiency caused by anti-PD-1 immune agents are relatively rare in clinical practice, so in this...
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Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury
BackgroundBronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating...
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Chronic lung allograft dysfunction
Lung transplantation remains the only cure for selected patients with advanced irreversible lung diseases. More than 4000 lung transplants are...
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Restrictive allograft dysfunction rather than bronchiolitis obliterans syndrome had a major impact on the overall survival after living-donor lobar lung transplantation
PurposeChronic lung allograft dysfunction (CLAD) is a known long-term fatal disorder after lung transplantation. In this study, we evaluated the CLAD...
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Cytomegalovirus Infection Is Associated with Development of Chronic Lung Allograft Dysfunction
BackgroundCytomegalovirus (CMV) is the major and most common opportunistic infection complicating lung transplant (LTX). The aim of this study was to...
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Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity
Background:Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV 1 ) in the setting of preserved ratio....
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The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study
BackgroundThe role of thyroid hormones in cancers has been discussed in observational studies; however, the causal relationship between them remains...
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Clinical impact of preoperative diaphragm dysfunction on early outcomes and ventilation function in lung transplant: a single-center retrospective study
BackgroundClinical impact of preoperative diaphragm dysfunction on lung transplantation has not been studied. We aimed to evaluate how preoperative...
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Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study
BackgroundSmall airway dysfunction (SAD), a hallmark of early lung function abnormality, is a major component of several chronic respiratory...
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Exploring the lung-gut direction of the gut-lung axis in patients with ARDS
Acute respiratory distress syndrome (ARDS) represents a life-threatening inflammatory reaction marked by refractory hypoxaemia and pulmonary oedema....
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Neutralization of CX3CL1 Attenuates TGF-β-Induced Fibroblast Differentiation Through NF-κB Activation and Mitochondrial Dysfunction in Airway Fibrosis
BackgroundSevere asthma, characterized by inflammation and airway remodeling, involves fibroblast differentiation into myofibroblasts expressing...
