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Reduced-toxicity conditioning regimen with low dose post-transplantation cyclophosphamide and low-dose anti-thymocyte globulin as graft-versus-host disease prophylaxis for haploidentical stem cell transplantation in older patients
Reduced-toxicity conditioning (RIC) regimens are used for allogeneic hematopoietic stem cell transplantation in older patients. However, successful...
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Transdermal Low-Dose Buprenorphine Induction to Transition a Patient off a Higher-Dose Methadone Regimen: a Case Report
Buprenorphine is a partial μ‐opioid agonist with high receptor binding affinity and long half-life—qualities that reduce overdose risk with...
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Decitabine combined with low-dose cytarabine, aclarubicin and rhG-CSF regimen may be a potential alternative for relapsed/refractory acute myeloid leukemia: A single-center study
PurposeTo analyze the effectiveness of decitabine combined with low-dose Ara‑C, aclarubicin, and rhG-CSF (DCAG) as a salvage therapy in patients with...
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Individualized regimen of low-dose rituximab monotherapy for new-onset AChR-positive generalized myasthenia gravis
BackgroundGeneralized AChR-MG is an archetype of B cell-mediated autoimmune disorders, and use of biologic agent rituximab (RTX) for B cell depletion...
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Low-dose prasugrel versus standard-dose ticagrelor in east Asian patients with acute coronary syndrome
Low-dose prasugrel demonstrated a similar effectiveness profile to clopidogrel in East Asian ACS patients, but its comparison with another...
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Unrelated umbilical cord blood transplantation with low-dose anti-thymocyte globulin for children with severe aplastic anemia: A case series
ObjectiveThis study aimed to investigate the prognosis of unrelated umbilical cord blood transplantation (UCBT) using low-dose anti-thymocyte...
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Early, low-dose hydrocortisone and near-term brain connectivity in extremely preterm infants
BackgroundPostnatal steroids are used to prevent bronchopulmonary dysplasia in extremely preterm infants but may have adverse effects on brain...
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Low-dose post-transplant cyclophosphamide with low-dose antithymocyte globulin for prevention of graft-versus-host disease in first complete remission undergoing 10/10 HLA-matched unrelated donor peripheral blood stem cell transplants: a multicentre, randomized controlled trial
The most widely used regimens of graft-versus-host disease (GVHD) prophylaxis in HLA-matched unrelated donor peripheral blood stem cell...
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Safety and efficacy of a low-dose combination of midazolam, alfentanil, and propofol for deep sedation of elderly patients undergoing ERCP
BackgroundProper sedation of patients, particularly elderly individuals, who are more susceptible to sedation-related complications, is of...
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High- and low-dose cyclophosphamide in Egyptian lupus nephritis patients: a multicenter retrospective analysis
BackgroundLupus nephritis (LN) is a common serious presentation of systemic lupus erythematosus. Cyclophosphamide (CYC) and mycophenolate mofetil...
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Efficacy of low-dose rituximab in minimal change disease and prevention of relapse
BackgroundMinimal change disease (MCD) is a major cause of nephrotic syndrome (NS) in children and a minority of adults. The higher tendency to...
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Low-Dose Initiation of Buprenorphine: A Narrative Review
Purpose of ReviewOpioid use disorder (OUD) is a chronic disorder in which a person loses control over the use of opioids, develops a compulsive...
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Effectiveness of low-volume split-dose versus same-day morning polyethylene glycol regimen for adequacy of bowel preparation in patients undergoing colonoscopy: A single-blinded randomized controlled trial
BackgroundSuccessful completion of colonoscopy depends largely on the quality of bowel preparation. Polyethylene glycol (PEG) is a commonly used...
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Comparable outcomes with low-dose and standard-dose horse anti-thymocyte globulin in the treatment of severe aplastic anemia
BackgroundThe standard dose (SD) of horse anti-thymocyte globulin (hATG) ATGAM (Pfizer, USA) or its biosimilar thymogam (Bharat Serum, India) for the...
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Perinatal outcomes of high dose versus low dose oxytocin regimen used for labor induction and factors associated with adverse perinatal outcome in four hospitals of Ethiopia: a multicenter comparative study
BackgroundThere is limited evidence on effect of high and low dose oxytocin used for labor induction on perinatal outcomes. We compared perinatal...
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Low dose rabbit antithymocyte globulin is non-inferior to higher dose in low-risk pediatric kidney transplant recipients
BackgroundCurrently, there is no consensus among pediatric kidney transplant centers regarding the use and regimen for immunosuppressive induction...
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Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial
BackgroundColonoscopy is a standard procedure for evaluating colon diseases and screening for colorectal cancer, and bowel cleanliness prior to...
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Aspirin with Low-Dose Ticagrelor or with Low-Dose Rivaroxaban for Secondary Prevention: A Cost per Outcome Analysis
IntroductionSecondary prevention of cardiovascular events among patients with diagnosed cardiovascular disease and high ischemic risk poses a...