Search
Search Results
-
Bojungikgi-tang improves skin barrier function and immune response in atopic dermatitis mice fed a low aryl hydrocarbon receptor ligand diet
BackgroundThe aryl hydrocarbon receptor (AhR) is a transcription factor that plays a crucial role in regulating the immune system and maintaining...
-
Impact of IDO activation and alterations in the kynurenine pathway on hyperserotonemia, NAD+ production, and AhR activation in autism spectrum disorder
Hyperserotonemia is the most replicated biochemical anomaly associated with autism spectrum disorder (ASD) and has been reported in 35–46% of...
-
Diet, Microbioma, and Diabetes in Aging
Purpose of ReviewTo describe the relationships between gut microbiota (GM), metabolism, immune system, and the association with the development of...
-
Perspectives on the involvement of the gut microbiota in salt-sensitive hypertension
Salt-sensitivity hypertension (SSH) is an independent predictor of cardiovascular event-related death. Despite the extensiveness of research on...
-
Contribution of the microbiome for better phenoty** of people living with obesity
Obesity has reached epidemic proportion worldwide and in all ages. Available evidence points to a multifactorial pathogenesis involving gene...
-
Early-life stress perturbs the epigenetics of Cd36 concurrent with adult onset of NAFLD in mice
BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the U.S. and worldwide. The roles of early postnatal...
-
Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods
BackgroundHypertension is one of the burning topics in today’s world. Natural product can open a new window in the treatment as they are lesser side...
-
Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin
Background/objectivesObesity is a global epidemic and the underlying basis for numerous comorbidities. We report that the aryl hydrocarbon receptor...
-
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and disease progression. Recently, dietary interventions...
-
Gut Microbiota and Its Role in the Brain-Gut-Kidney Axis in Hypertension
Purpose of ReviewThe role of the gut microbiota in modulating blood pressure is increasingly being recognized, currently. The purpose of this review...
-
Identification of potential key lipid metabolism-related genes involved in tubular injury in diabetic kidney disease by bioinformatics analysis
AimsAccumulating evidences indicate that abnormalities in tubular lipid metabolism play a crucial role in the development of diabetic kidney disease...
-
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis
BackgroundFerroptosis, a type of programmed cell death triggered by oxidative stress, was suspected to play a role in ulcerative colitis. Indigo...
-
AHR in the intestinal microenvironment: safeguarding barrier function
Mammalian aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that belongs to the basic helix–loop–helix (bHLH)–PAS family of...
-
-
Oncometabolites in cancer: from cancer cells to the tumor microenvironment
Oncometabolites refer to pro-oncogenic metabolites that are aberrantly accumulated due to distorted metabolic pathways in cancer cells, and play a...
-
The roles of the kynurenine pathway in COVID-19 neuropathogenesis
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the highly contagious respiratory disease Corona Virus...
-
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Overweight and obesity are characterized by excessive fat mass accumulation produced when energy intake exceeds energy expenditure. One plausible way...
-
New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of the gut–brain axis, intestinal permeability, mucosal...
-
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the gut microbiota is a key player in communication between...
-
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma
Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma (HCC) in individuals infected with the...
