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Total neoadjuvant therapy for each locally advanced rectal cancer?
The treatment paradigm for locally advanced rectal cancer has changed in recent years. Neoadjuvant radiochemotherapy followed by total mesorectal...
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Current neoadjuvant therapy for operable locally advanced esophageal cancer
Locally advanced esophageal cancer has a poor prognosis, while an increasing number of patients are diagnosed with that. Neoadjuvant therapy has...
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Futibatinib: A Review in Locally Advanced and Metastatic Cholangiocarcinoma
Futibatinib (LYTGOBI ® ) is an oral small molecule compound that selectively, irreversibly and potently inhibits the tyrosine kinase activity of...
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Pathological complete response following neoadjuvant chemotherapy for locally advanced intrahepatic cholangiocarcinoma
BackgroundIntrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Cases when found are often advanced with vascular...
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Molecular features and prognostic factors of locally advanced microsatellite instability-high gastric cancer
BackgroundMicrosatellite instability-high (MSI-H) tumors are distinct molecular subtypes in gastric cancer. However, a few studies have...
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Influence of Neoadjuvant Immunotherapy–Chemotherapy on Perioperative Outcomes in Locally Advanced Esophageal Adenocarcinoma
BackgroundThis study evaluated the perioperative outcomes for patients who had locally advanced esophageal adenocarcinoma (EAC) treated with...
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Analysis of influencing factors of nerve invasion in locally advanced gastric cancer
ObjectivesAccurate preoperative diagnosis of locally advanced gastric cancer (GC) with nerve invasion is very important for guiding the clinical...
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Management of patients with extensive locally advanced thyroid cancer: results of multimodal treatments
PurposeSurgery plays a key role in the treatment of thyroid cancer (TC) patients. Locally advanced cases, however, can require an extensive surgical...
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Locally advanced thymoma; does neoadjuvant chemotherapy make a difference?
BackgroundRegardless of its rare occurrence, Thymoma remains the most frequently encountered primary tumor of the anterior mediastinum comprising...
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Survival outcomes of neoadjuvant immunochemotherapy versus chemotherapy for locally advanced esophageal squamous cell carcinoma
PurposeNeoadjuvant chemotherapy (NCT) is the standard preoperative treatment for resectable locally advanced esophageal squamous cell carcinoma...
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Future direction of total neoadjuvant therapy for locally advanced rectal cancer
Despite therapeutic advancements, disease-free survival and overall survival of patients with locally advanced rectal cancer have not improved in...
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Avelumab as First-Line Maintenance Treatment in Locally Advanced or Metastatic Urothelial Carcinoma
This work provides a summary of guideline recommendations and an expert position on the use of maintenance avelumab therapy based on a review of...
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Safety and efficacy of helical tomotherapy following lung-sparing surgery in locally advanced malignant pleural mesothelioma
PurposeTo assess the value of radiation therapy (RT) with helical tomotherapy (HT) in the management of locally advanced malignant pleural...
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Current Approaches to the Management of Locally Advanced Pancreatic Cancer
Purpose of ReviewPancreatic cancer is one of the deadliest malignancies in the United States and the world. The Current standard of treatment fails...
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Neoadjuvant Chemotherapy Improves Feasibility of Larynx Preservation and Prognosis in Resectable Locally Advanced Cervical Esophageal Cancer
BackgroundThe optimal strategy for cervical advanced esophageal cancer remains controversial in terms of oncologic outcome as well as vocal and...
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Preoperative Strategies for Locally Advanced Colon Cancer
Neoadjuvant chemotherapy is safe for patients with locally advanced colon cancer (LACC). The FOxTROT trial demonstrated a reduction in residual and...
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Adjuvant treatment for locally advanced gastric cancer: an Asian perspective
Standard adjuvant treatment for locally advanced gastric cancer (LAGC) is regionally different. Whereas perioperative chemotherapy is the standard in...
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Chemoradiotherapy vs radiotherapy for non-surgical locally advanced laryngeal squamous cell carcinoma patients: a propensity score-matched study and practical nomogram construction
ObjectiveTo compare the cancer-specific survival (CSS) among patients with locally advanced laryngeal squamous cell carcinoma (LSCC) receiving...
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Survival benefit of surgery with postoperative radiotherapy in locally advanced cervical adenocarcinoma: a population-based analysis
BackgroundThe incidence of cervical adenocarcinoma (AC) has experienced a considerable increase in recent decades. Despite this, our understanding of...
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Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer
Surgical resection combined with systemic chemotherapy is the cornerstone of treatment for patients with localized pancreatic cancer. Upfront surgery...
