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Linkage Disequilibrium Score Statistic Regression for Identifying Novel Trait Associations
Purpose of ReviewIn this paper, we review the linkage disequilibrium score regression (LDSR) statistical method for computing correlation and shared...
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Linkage and association of variants in the dopamine receptor 2 gene (DRD2) with polycystic ovary syndrome
Polycystic ovarian syndrome (PCOS) is a disorder with a foundation of neuroendocrine dysfunction, characterized by increased gonadotropin-releasing...
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Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome
BackgroundWomen with polycystic ovarian syndrome (PCOS) have increased hypothalamic–pituitary–adrenal (HPA) axis activation, pro-inflammatory...
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DNMT1 SNPs (rs2114724 and rs2228611) associated with positive symptoms in Chinese patients with schizophrenia
ObjectiveSchizophrenia is a serious mental disorder with complex clinical manifestations, while its pathophysiological mechanism is not fully...
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The melatonin receptor genes are linked and associated with the risk of polycystic ovary syndrome
Polycystic ovarian syndrome (PCOS) is a genetically complex disorder that involves the interplay of multiple genes and environmental factors. It is...
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The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families
ObjectivesComponents of the hypothalamic-pituitary axis (HPA) pathway are potential mediators of the genetic risk of polycystic ovarian syndrome...
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LD block disorder-specific pleiotropic roles of novel CRHR1 in type 2 diabetes and depression disorder comorbidity
Major depressive disorder (MDD) and type 2 diabetes (T2D) are complex disorders whose comorbidity can be due to hypercortisolism and may be explained...
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Fluoropyrimidine-associated toxicity and DPYD variants c.85T>C, c.496A>G, and c.1236G>A: impact of haplotype
Dihydropyrimidine dehydrogenase ( DPYD ) is the rate-limiting step in fluoropyrimidines metabolism. Currently, genotype-guided fluoropyrimidine dosing...
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LEP (G2548A-G19A) and ADIPOQ (T45G-G276T) gene polymorphisms are associated with markers for metabolic syndrome
Background and aimsThere is a link between genetics with metabolic balance and adiposity homeostasis on metabolic syndrome (MetS). Polymorphism in...
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The association of APOH and NCF1 polymorphisms on susceptibility to recurrent pregnancy loss in women with antiphospholipid syndrome
BackgroundRecurrent pregnancy loss (RPL) is the main manifestation of pathological pregnancy in antiphospholipid syndrome (APS) women. The immune...
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Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China
BackgroundAtrial septal defect (ASD) is a common form of congenital heart disease. Although several genes related to ASD have been found, the genetic...
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A genetic correlation scan identifies blood proteins associated with bone mineral density
BackgroundOsteoporosis is a common metabolic bone disease that is characterized by low bone mass. However, limited efforts have been made to explore...
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Relationship between BDNF gene polymorphisms and alcohol-related liver cirrhosis
Background and aimBrain-derived neurotrophic factor (BDNF) functions not only in the brain but also in peripheral tissues such as the liver. Genetic...
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Association between inflammatory bowel disease and cancer risk: evidence triangulation from genetic correlation, Mendelian randomization, and colocalization analyses across East Asian and European populations
BackgroundInflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer...
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Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases
BackgroundDespite substantial research revealing that patients with rheumatoid arthritis (RA) have excessive morbidity and mortality of...
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Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability
Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many...
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Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
BackgroundWe aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD).
Methods ...
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Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance
BackgroundObstructive sleep apnea (OSA) is a pervasive, chronic sleep-related respiratory condition that causes brain structural alterations and...
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Acute pancreatitis and metabolic syndrome: genetic correlations and causal associations
BackgroundAlthough there is a definite correlation between the Metabolic Syndrome (MetS) and Acute Pancreatitis (AP), cause is yet unknown. The...
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Genetically predicted effects of physical activity and sedentary behavior on myasthenia gravis: evidence from mendelian randomization study
BackgroundMyasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction. Despite the potential benefits of higher physical...
