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TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy
Photodynamic therapy (PDT) is an emerging clinical treatment that is expected to become an important adjuvant strategy for the immunotherapeutic...
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Efficacy and safety of low-level light therapy by delicate pulsed light combined with low-dose oral isotretinoin for the treatment of acne vulgaris: a randomized split-face study
Acne vulgaris (AV) is a common dermatosis that causes psychological problems. Isotretinoin is the first-line treatment for moderate-to-severe AV, but...
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Employing Multiple Low-Dose PET Images (at Different Dose Levels) as Prior Knowledge to Predict Standard-Dose PET Images
The existing deep learning-based denoising methods predicting standard-dose PET images (S-PET) from the low-dose versions (L-PET) solely rely on a...
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No-Dose Photodynamic Therapy Against Half-Dose Photodynamic Therapy for Treatment of Central Serous Chorioretinopathy
IntroductionThis study aimed to describe the effects of no-dose full-fluence photodynamic therapy without verteporfin (no-dose PDT) and to compare...
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Novel method for calculating the effective dose using size-specific dose estimates conversion factors in abdomen–pelvis computed tomography
We propose a novel method for calculating the effective dose that closely reflects the individual attenuation, utilizing two conversion coefficients....
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Light at night and risk of breast cancer: a systematic review and dose–response meta-analysis
Breast cancer is the most common malignancy in women and the second leading cause of cancer death overall. Besides genetic, reproductive, and...
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The 50% effective dose of hydromorphone and morphine for epidural analgesia in the hemorrhoidectomy: a double-blind, sequential dose-finding study
BackgroundAlthough previous studies have showed that epidural morphine can be used as a complement to local anesthetics for analgesia after...
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Efficacy and Safety of Trazodone and Gabapentin Fixed-Dose Combination in Patients Affected by Painful Diabetic Neuropathy: Randomized, Controlled, Dose-Finding Study
IntroductionUp to 50% of diabetic patients with neuropathy suffer from chronic pain, namely painful diabetic neuropathy (PDN), an unmet medical need...
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Comparative study between efficacy of Excimer light with topical Tacrolimus 0.1% versus excimer light with topical Bimatoprost 0.01% in treatment of facial Vitiligo
Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation. The aim...
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Effective remimazolam loading dose for adequate sedation in regional anesthesia
PurposeRemimazolam is a novel ultrashort-acting sedative considered appropriate for continuous infusion during surgical procedures. Nevertheless,...
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Comparison of Low-Dose Non-contrast CT in Detecting Anatomical and Surgically Important Variants of Paranasal Sinuses to Standard Dose Non-contrast CT: Experience from a Tertiary Care Hospital in Sub-Himalayan Region of Northern India
Computed tomography (CT) is the gold standard for diagnosing sinusitis and anatomical variations and a guide for paranasal sinus (PNS) surgeries....
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Blue Light Exposure: Ocular Hazards and Prevention—A Narrative Review
IntroductionExposure to blue light has seriously increased in our environment since the arrival of light emitting diodes (LEDs) and, in recent years,...
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The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients
BackgroundNorepinephrine (NE) is a cornerstone drug in the management of septic shock, with its dose being used clinically as a marker of disease...
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Personalized venlafaxine dose prediction using artificial intelligence technology: a retrospective analysis based on real-world data
BackgroundVenlafaxine dose regimens vary considerably between individuals, requiring personalized dosing.
AimThis study aimed to identify...
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Reduced post-transplant cyclophosphamide dose with antithymocyte globulin in peripheral blood stem cell haploidentical transplantation
Post-transplant cyclophosphamide (PT-Cy) is effective for graft-versus-host disease (GVHD) prophylaxis, but it may cause dose-dependent toxicities,...
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Identification of the ideal weight-based indocyanine green dose for fluorescent cholangiography
BackgroundIdeal visualization of fluorescent cholangiography during laparoscopic cholecystectomy is when maximum fluorescence into biliary ducts and...
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High-dose versus low-dose venous thromboprophylaxis in hospitalized patients with COVID-19: a systematic review and meta-analysis
BackgroundHospitalized COVID-19 patients are at high risk of venous thromboembolism (VTE). Standard doses of anticoagulant prophylaxis may not be...
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Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations
PurposeEntrectinib is a central nervous system-active potent inhibitor of tropomyosin receptor kinase (TRK), with anti-tumor activity against...
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First-in-human phase I dose-escalation and dose-expansion trial of the selective MEK inhibitor HL-085 in patients with advanced melanoma harboring NRAS mutations
BackgroundHL-085 is a selective, orally administered MEK1/2 inhibitor. We aimed to evaluate the safety and efficacy of HL-085 in patients with...
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Voxel-based tumor dose correlates to complete pathologic necrosis after transarterial radioembolization for hepatocellular carcinoma
PurposeThe transarterial radioembolization (TARE) dose is traditionally calculated using the single-compartment Medical Internal Radiation Dose...
