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Fenfluramine for the Treatment of Dravet Syndrome and Lennox Gastaut Syndrome: A Review
Purpose of ReviewTreatment-resistant epilepsy comprises approximately 36.3% of neurology clinic-based populations in the USA. Despite new drug...
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Fenfluramine for the treatment of status epilepticus: use in an adult with Lennox–Gastaut syndrome and literature review
BackgroundNovel treatments are needed to control refractory status epilepticus (SE). This study aimed to assess the potential effectiveness of...
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A survey of preferences and expectations for surgical interventions targeting atonic seizures in Lennox-Gastaut syndrome
PurposeTo assess preferences and outcome expectations for vagus nerve stimulation (VNS) and corpus callosotomy (CC) surgeries in the treatment of...
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The burden of illness in Lennox–Gastaut syndrome: a systematic literature review
BackgroundLennox–Gastaut syndrome (LGS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant epilepsy with multiple...
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Fenfluramine: A Review in Dravet and Lennox-Gastaut Syndromes
Fenfluramine (Fintepla ® ) is an oral anti-seizure medication (ASM) with a novel mechanism of action consisting of activity in the serotonergic system...
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Fenfluramine in clinical practice: new therapy option for Dravet and Lennox–Gastaut syndromes
Fenfluramine is an antiseizure medication for the treatment of Dravet and Lennox–Gastaut syndromes. This review summarizes the literature on the...
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Comorbidities in Dravet Syndrome and Lennox–Gastaut Syndrome
This study aims to describe the main cognitive and behavioral comorbidities of Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS), their impact...
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Efficacy analysis of oral dexamethasone in the treatment of infantile spasms and infantile spasms related Lennox–Gastaut syndrome
ObjectiveTreatment with adrenocorticotropic hormone (ACTH) or a corticosteroid is the first choice for infantile spasms (IS), and vigabatrin is the...
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Development of localized interictal epileptiform discharges following vagus nerve stimulation for lennox-gastaut syndrome: a case report
BackgroundLennox-gastaut syndrome (LGS) is an epileptic encephalopathy often associated with behavioral and psychiatric disorders. Vagus nerve...
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Truncating mutation in TANC2 in a Chinese boy associated with Lennox-Gastaut syndrome: a case report
BackgroundLennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy that can be caused by brain malformations or genetic mutations....
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Lennox–Gastaut Syndrome: Perspective of a Parent and a Physician
This article is co-authored by a parent of a 32-year-old male patient with Lennox–Gastaut syndrome (LGS) and his epileptologist. It discusses the...
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Kallosotomie bei Lennox-Gastaut-Syndrom
Corpus callosotomy is a palliative therapy option in patients with drop attacks or therapy-resistant bilateral tonic-clonic seizures (BTCS),...
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Clinical Trial Outcome Measurements in Lennox-Gastaut Syndrome and Their Application to the Development of Targeted Treatments
Purpose of ReviewLennox-Gastaut syndrome (LGS) is an epileptic encephalopathy that is challenging to treat, with >80% of patients remaining...
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Highly Purified Cannabidiol for Epilepsy Treatment: A Systematic Review of Epileptic Conditions Beyond Dravet Syndrome and Lennox–Gastaut Syndrome
BackgroundCannabidiol (CBD), which is one major constituent of the Cannabis sativa plant, has anti-seizure properties and does not produce euphoric...
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Lennox-Gastaut-Syndrom: Wie behandeln?
The Lennox-Gastaut syndrome (LGS) is a rare and age-dependent epileptic encephalopathy and is difficult to treat. It presents with variable seizure...
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Expanding the Treatment Landscape for Lennox-Gastaut Syndrome: Current and Future Strategies
Lennox-Gastaut syndrome (LGS), a childhood-onset severe developmental and epileptic encephalopathy (DEE), is an entity that encompasses a...
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Fenfluramine for the Treatment of Dravet Syndrome and Lennox–Gastaut Syndrome
The last 50 years has seen the introduction of a great number of antiepileptic drugs, relieving the burden of seizures for many patients. However,...
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Efficacy and safety of corpus callosotomy and ketogenic diet in children with Lennox Gastaut syndrome: a systematic review and meta-analysis
BackgroundBoth corpus callosotomy (CC) and the ketogenic diet (KD) are commonly used in patients with Lennox Gastaut syndrome (LGS), as a significant...
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Epilepsy and other comorbidities in Down syndrome
Down syndrome (DS) is the most common cause of intellectual disability. Due to many genetic and biochemical aberrations, people with DS suffer from...
