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The parabrachial to central amygdala pathway is critical to injury-induced pain sensitization in mice
The spino-ponto-amygdaloid pathway is a major ascending circuit relaying nociceptive information from the spinal cord to the brain. Potentiation of...
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Selective optogenetic modulation of the PBN terminals in the lateral hypothalamic area and basal forebrain regulates emergence from isoflurane anesthesia in mice
While the mechanism of general anesthesia has been extensively studied, the underlying neural circuitry has yet to be fully understood. The...
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The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking
The parasubthalamic nucleus (PSTN) is activated by refeeding after food deprivation and several PSTN subpopulations have been shown to suppress...
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Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine
BackgroundMigraine is one of the world’s most prevalent and disabling diseases. Despite huge advances in neuroimaging research, more valuable...
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Nucleus of the solitary tract A2 neurons control feeding behaviors via projections to the paraventricular hypothalamus
Hindbrain NTS neurons are highly attuned to internal physiological and external environmental factors that contribute to the control of food intake...
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Repeat mild traumatic brain injuries (RmTBI) modify nociception and disrupt orexinergic connectivity within the descending pain pathway
Repeat mild traumatic brain injuries (RmTBI) result in substantial burden to the public health system given their association with chronic...
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Sleep apnea pathophysiology
ObjectiveThe purpose of this study is to examine the pathophysiology underlying sleep apnea (SA).
BackgroundWe consider several critical features of...
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Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study
BackgroundThe pathogenesis of migraine chronification remains unclear. Functional and structural magnetic resonance imaging studies have shown...
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Tractography patterns of pedunculopontine nucleus deep brain stimulation
Deep brain stimulation of the pedunculopontine nucleus is a promising surgical procedure for the treatment of Parkinsonian gait and balance...
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Study on reverse transsynaptic virus tracing targeting Shenmen (HT7) and heart in mice
ObjectiveTo investigate the neural connections between Shenmen (HT7)-heart and the brain by observing the tracing viruses co-labeled brain nuclear...
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The deletion of glucagon-like peptide-1 receptors expressing neurons in the dorsomedial hypothalamic nucleus disrupts the diurnal feeding pattern and induces hyperphagia and obesity
BackgroundFeeding rhythm disruption contributes to the development of obesity. The receptors of glucagon-like peptide-1 (GLP-1) are distributed in...
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Homologies of spinal ascending nociceptive pathways between rats and macaques: can we transpose to human? A review and analysis of the literature
PurposeDue to the difficulty of using neural tracers in humans, knowledge of the nociceptive system’s anatomy is mainly derived from studies in...
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Neural Control of REM Sleep and Motor Atonia: Current Perspectives
Purpose of ReviewSince the formal discovery of rapid eye movement (REM) sleep in 1953, we have gained a vast amount of knowledge regarding the...
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Brainstem anatomy with 7-T MRI: in vivo assessment and ex vivo comparison
BackgroundThe brainstem contains grey matter nuclei and white matter tracts to be identified in clinical practice. The small size and the low...
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The influence of the subcortex and brain stem on overeating: How advances in functional neuroimaging can be applied to expand neurobiological models to beyond the cortex
Functional neuroimaging has become a widely used tool in obesity and eating disorder research to explore the alterations in neurobiology that...
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Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain
Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of...
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A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder
Deep brain stimulation (DBS) is a promising treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, nine participants...
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Direct paraventricular thalamus-basolateral amygdala circuit modulates neuropathic pain and emotional anxiety
The comorbidity of chronic pain and mental dysfunctions such as anxiety disorders has long been recognized, but the underlying mechanisms remained...
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Brainstem impairment in obstructive sleep apnoea and the effect of CPAP treatment: an electrophysiological blink reflex study
PurposeThis study aimed to evaluate the functionality of the brainstem structures through the blink reflex (BR) test in patients with obstructive...
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