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LPA1 receptors in the lateral habenula regulate negative affective states associated with alcohol withdrawal
The role of lysophosphatidic acid (LPA) signaling in psychiatric disorders and drug abuse is significant. LPA receptors are widely expressed in the...
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The contribution of lysophosphatidic acid receptors in the response of human lower esophageal sphincter under the electrical field stimulation
BackgroundThis study aims to identify the impact on the reaction while the clasp and sling fibers of the human lower esophageal sphincter are under...
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Plasma concentrations of lysophosphatidic acid and the expression of its receptors in peripheral blood mononuclear cells are altered in patients with cocaine use disorders
We have recently reported alterations in the plasma concentrations of lysophosphatidic acid (LPA) in patients with substance use disorders. In order...
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Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in cardiovascular diseases. Here, we question whether LPA...
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Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects
Lysophospholipids are a class of bioactive lipid molecules that produce their effects through various G protein-coupled receptors (GPCRs)....
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Neue Therapieverfahren für die idiopathische Lungenfibrose am Horizont
BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal age-related lung disease with limited treatment options.
ObjectiveThis article gives an...
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LPA3 is a precise therapeutic target and potential biomarker for ovarian cancer
Current studies have demonstrated that significant increased LPA levels to be observed in ascites in patients with ovarian cancer. Although several...
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The LPA-CDK5-tau pathway mediates neuronal injury in an in vitro model of ischemia-reperfusion insult
Lysophosphatidic acid (LPA) is a common glycerol phospholipid and an important extracellular signaling molecule. LPA binds to its receptors and...
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LPA1 antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a debilitating lung disease with limited treatment options. A phase 2 trial (NCT01766817) showed...
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Different Profiles of the Triad of Lysophosphatidylcholine, Lysophosphatidic Acid, and Autotaxin in Patients with Neuropathic Pain Diseases: a Preliminary Observational Study
The mechanisms underlying neuropathic pain remain unclear. Lysophosphatidic acid (LPA) is a bioactive phospholipid derived mainly from...
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Lysophosphatidic Acid-Mediated Inflammation at the Heart of Heart Failure
Purpose of ReviewThe primary aim of this review is to provide an in-depth examination of the role bioactive lipids—namely lysophosphatidic acid (LPA)...
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Identification of immune associated potential molecular targets in proliferative diabetic retinopathy
BackgroundDiabetic retinopathy (DR) is one of the most common microvascular complications of diabetes and causes of blindness in developed countries....
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Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) remains a disease with poor survival. The pathogenesis is complex and encompasses multiple molecular pathways....
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Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis
BackgroundLysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA 1–6 ), and serves...
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Pathological progression of osteoarthritis: a perspective on subchondral bone
Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global aging population has led to a surge in OA cases, thereby...
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Emerging advanced approaches for diagnosis and inhibition of liver fibrogenesis
BackgroundLiver fibrosis results from chronic liver injury and is characterized by excessive deposition of extracellular matrix proteins including...
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The Multiple Functions of HB-EGF in Female Reproduction and Related Cancer: Molecular Mechanisms and Targeting Strategies
Heparin-binding growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) ligand family which has a crucial role in women’s health....
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Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies
Systemic sclerosis is the rheumatic disease with the highest individual mortality. The severity of the disease is determined by the extent of...
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Identification of lipid metabolism-related gene signature in the bone marrow microenvironment of multiple myelomas through deep analysis of transcriptomic data
Dysregulated lipid metabolism in the bone marrow microenvironment (BMM) plays a vital role in multiple myeloma (MM) development, progression, and...
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An update on targeted therapies in systemic sclerosis based on a systematic review from the last 3 years
New molecular mechanisms that can be targeted with specific drugs have recently emerged for the treatment of systemic sclerosis (SSc) patients. Over...
