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Human antimicrobial peptide LL-37 contributes to Alzheimer’s disease progression
As a prime mover in Alzheimer’s disease (AD), microglial activation requires membrane translocation, integration, and activation of the metamorphic...
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Efficacy of LL-37 cream in enhancing healing of diabetic foot ulcer: a randomized double-blind controlled trial
Wound healing in DFU (diabetic foot ulcer) has prolonged inflammation phase and defective granulation tissue formation. LL-37 has antimicrobial...
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The long-term prognostic value of serum 25(OH)D, albumin, and LL-37 levels in acute respiratory diseases among older adults
BackgroundOlder adults are more susceptible to respiratory tract infection than healthy working age adults. The increased susceptibility of older...
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Chitosan hydrogel encapsulated with LL-37 peptide promotes deep tissue injury healing in a mouse model
BackgroundLL-37 peptide is a member of the human cathelicidin family, and has been shown to promote the healing of pressure ulcers. However, the low...
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Vitamin D and LL-37 in cirrhotic patients with culture-positive spontaneous bacterial peritonitis
Abstract
Background and aimsSpontaneous bacterial peritonitis (SBP) is a common bacterial infection in patients with liver cirrhosis and ascites....
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Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37
BackgroundAirway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of...
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Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells
ObjectiveGlioblastoma multiforme (GBM) is the most aggressive and fatal malignant primary brain tumor. The enhancement of the survival rate for...
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Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis
Although vitamin D (VD) is known to have multiple effects on the skin and immunity, its effects on atopic dermatitis (AD) severity remain unclear. We...
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Comparison of frailty in patients with nontuberculous mycobacterial lung disease and bronchiectasis: a prospective cohort study
BackgroundThe incidence of nontuberculous mycobacterial lung disease (NTM-LD) peaks in middle- and old age groups, coinciding with senescence; thus,...
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Correlation between strength/endurance of paraspinal muscles and sagittal parameters in patients with degenerative spinal deformity
BackgroundSagittal imbalance is a common cause of low back pain and dysfunction in patients with degenerative spinal deformity (DSD), which greatly...
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The effect of gum Arabic supplementation on cathelicidin expression in monocyte derived macrophages in mice
BackgroundAntimicrobial peptides (AMPs) are important effectors of the innate defense system. Cathelicidins, (CRAMP in mouse/rat, LL-37 in human) is...
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Purinergic P2X7R as a potential target for pancreatic cancer
Pancreatic cancer is one of the deadliest types of cancer, with a death rate nearly equal to the incidence. The P2X7 receptor (P2X7R) is a kind of...
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The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer
BackgroundMethylated SDC2 and TFPI2 are widely used for colorectal cancer (CRC) detection. However, they often miss some CRCs, which directly...
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Cord blood antimicrobial peptide LL37 levels in preterm neonates and association with preterm complications
BackgroundCathelicidin/LL-37 plays a significant role in the human immune defense reaction. Preterm human immature organs being exposed to...
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An Emerging Role of Extracellular Traps in Chronic Rhinosinusitis
Purpose of ReviewChronic rhinosinusitis (CRS) is a complicated, heterogeneous disease likely caused by inflammatory and infectious factors. There is...
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Influence of posterior instrumented correction with pedicle screw dual rod systems on thoracic kyphosis in Lenke 1 and 2 curves: minimum 2 years follow-up
PurposeAdolescent idiopathic scoliosis (AIS) often correspond with hypo thoracic kyphosis (TK) or even lordosis. The aim of this study was to analyze...
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Identification of an optimal dose of intravenous ketamine for late-life treatment-resistant depression: a Bayesian adaptive randomization trial
Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD) is necessary. This study used Bayesian adaptive...
