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Schwanger werden nach Krebs – Chancen, Risiken und Unterstützungsmöglichkeiten?
BackgroundIn the coming years a further increase in cancer cases is to be expected among young women of reproductive age.
ObjectiveWhat impact does...
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Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN ( Taz ), required for the synthesis...
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The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry
The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation...
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How arrhythmias weaken the ventricle: an often underestimated vicious cycle
Arrhythmia-induced cardiomyopathy (AIC) is classified as a form of dilated cardiomyopathy in which left ventricular systolic dysfunction (LVSD) is...
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Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria
Metabolic reprogramming (MR) influences progression of chronic myeloid leukaemia (CML) to blast crisis (BC), but metabolic programs may change...
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The functional roles of TCA cycle metabolites in cancer
The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for generating cellular energy and precursors for biosynthetic pathways....
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Type 2 diabetes and succinate: unmasking an age-old molecule
Beyond their conventional roles in intracellular energy production, some traditional metabolites also function as extracellular messengers that...
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Exploring mitochondrial biomarkers for Friedreich's ataxia: a multifaceted approach
This study presents an in-depth analysis of mitochondrial enzyme activities in Friedreich's ataxia (FA) patients, focusing on the Electron Transport...
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Management of late onset urea cycle disorders—a remaining challenge for the intensivist?
BackgroundHyperammonemia caused by a disorder of the urea cycle is a rare cause of metabolic encephalopathy that may be underdiagnosed by the adult...
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Two cases of gastric cancer with elevated serum levels of KL-6
BackgroundThe serum level of Krebs von den Lungen-6 (sKL-6) is a biomarker of interstitial pneumonia and has been reported to be elevated in patients...
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Identification of potential biomarkers and metabolic pathways based on integration of metabolomic and transcriptomic data in the development of breast cancer
ObjectiveBreast cancer (BC) is the most common type of malignant tumor and the most common cause of cancer-related mortality among women. Metabolic...
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Mitochondrial Damage and Hypertension: Another Dark Side of Sodium Excess
Purpose of ReviewEssential or primary hypertension (HT) is a worldwide health problem with no definitive cure. Although the exact pathogenesis of HT...
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Current Management of Hepatic Encephalopathy
Purpose of ReviewHepatic encephalopathy (HE) is a complication of liver dysfunction and portosystemic shunting. The purpose of this review is to...
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Searching molecular biomarkers correlating with BSID-III at 24 months in infants with neonatal hypoxic-ischemic encephalopathy
An early prediction of outcomes of neonatal hypoxic-ischemic encephalopathy (NE) is of key importance in reducing neonatal mortality and morbidity....
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Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge
BackgroundThe heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and...
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Cellular and mitochondrial mechanisms of atrial fibrillation
The molecular mechanisms underlying atrial fibrillation (AF), the most common form of arrhythmia, are poorly understood and therefore target-specific...
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Cardioprotective effect of St. Thomas’ Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice
ObjectiveThis study aimed to investigate whether St. Thomas’ Hospital No. 2 solution (STH2) is equally effective in both young and aged...
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Regular transient limb ischemia improves endothelial function and inhibits endothelial cell apoptosis to prevent atherosclerosis in rabbit
AimsRegular transient limb ischemia (RTLI) can prevent atherosclerosis (AS) progression in hypercholesterolemic rabbits. This study aimed to...
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Efficacy and tolerability of a specific blend of amino acids in patients with anorexia nervosa treated in a hospital setting: study protocol for a randomized controlled trial
BackgroundSpecific blends of essential amino acids (EAA) containing a high percentage of branched-chain amino acids preserves mitochondrial...
