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Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies
Pharmacokinetic modelling with arterial sampling is the gold standard for analysing dynamic PET data of the brain. However, the invasive character of...
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First results on kinetic modelling and parametric imaging of dynamic 18F-FDG datasets from a long axial FOV PET scanner in oncological patients
PurposeTo investigate the kinetics of 18 F-fluorodeoxyglucose ( 18 F-FDG) by positron emission tomography (PET) in multiple organs and test the...
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Determining the optimal pharmacokinetic modelling and simplified quantification method of [18F]AlF-P16-093 for patients with primary prostate cancer (PPCa)
PurposeThis paper discusses the optimization of pharmacokinetic modelling and alternate simplified quantification method for [ 18 F]AlF-P16-093, a...
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Kinetic 18F-FDG PET/CT imaging of hepatocellular carcinoma: a dual input four-compartment model
BackgroundThe endoplasmic reticulum plays an important role in glucose metabolism and has not been explored in the kinetic estimation of...
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Pharmacokinetic studies of [68 Ga]Ga-PSMA-11 in patients with biochemical recurrence of prostate cancer: detection, differences in temporal distribution and kinetic modelling by tissue type
Purpose[ 68 Ga]Ga-PSMA-11 is a promising radiopharmaceutical for detecting tumour lesions in prostate cancer, but knowledge of the pharmacokinetics...
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Challenges in Pharmacokinetic Modelling of [18F]fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer Patients
PurposeTo describe the pharmacokinetic properties of the [ 18 F]fluoro-polyethylene glycol(PEG)-folate radiotracer in PET/CT imaging of patients with...
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Evaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach
Background and ObjectiveChronic kidney disease (CKD) may alter drug renal elimination but is also known for interacting with hepatic metabolism via...
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First experiences with dynamic renal [68Ga]Ga-DOTA PET/CT: a comparison to renal scintigraphy and compartmental modelling to non-invasively estimate the glomerular filtration rate
PurposeThe determination of the glomerular filtration rate (GFR) is decisive for a variety of clinical issues, for example, to monitor the renal...
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Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain
PurposeTo provide a comprehensive assessment of the novel 18 kDa translocator protein (TSPO) radiotracer, [ 18 F]LW223, kinetics in the heart and...
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Dose–Response Modelling of Resistance Exercise Across Outcome Domains in Strength and Conditioning: A Meta-analysis
BackgroundResistance exercise is the most common training modality included within strength and conditioning (S&C) practice. Understanding...
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Applying dynamic contrast-enhanced MRI tracer kinetic models to differentiate benign and malignant soft tissue tumors
BackgroundTo explore the potential of different quantitative dynamic contrast-enhanced (qDCE)-MRI tracer kinetic (TK) models and qDCE parameters in...
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Kinetic Modelling and Test–Retest Reproducibility for the Dopamine D1R Radioligand [11C]SCH23390 in Healthy and Diseased Mice
PurposeOur aim in this study was to compare different non-invasive pharmacokinetic models and assess test–retest reproducibility of the radioligand [
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Multivariable prognostic modelling to improve prediction of colorectal cancer recurrence: the PROSPeCT trial
ObjectiveImproving prognostication to direct personalised therapy remains an unmet need. This study prospectively investigated promising CT, genetic,...
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Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment
BackgroundTo compare two tracer kinetic models in predicting of preoperative risk types in endometrial carcinoma (EC) using DCE-MRI.
Methods ...
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Can 3D imaging modeling recognize functional tissue and predict liver failure? A retrospective study based on 3D modelling of the major hepatectomies after hepatic modulation
BackgroundThanks to the introduction of radiomics, 3d reconstruction can be able to analyse tissues and recognise true hypertrophy from...
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Mean kinetic temperature evaluations through simulated temperature excursions and risk assessment with oral dosage usage for health programs
BackgroundTemperature excursions occur during the transport and storage of pharmaceuticals, and often result in considerable losses for public health...
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Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [11C]PHNO brain PET-MR studies
IntroductionQ.Clear is a Bayesian penalised likelihood (BPL) reconstruction algorithm available on General Electric (GE) Positron Emission Tomography...
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A neuromusculoskeletal modelling approach to bilateral hip mechanics due to unexpected lateral perturbations during overground walking
BackgroundCurrent studies on how external perturbations impact gait dynamics have primarily focused on the changes in the body's center of mass (CoM)...
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Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements
BackgroundKinetic modelling of dynamic PET typically requires knowledge of the arterial radiotracer concentration (arterial input function, AIF). Its...
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Dynamic planar scintigraphy for the rapid kinetic measurement of myocardial 123I-MIBG turnover can identify Lewy body disease
BackgroundUsing two static scans for 123 I-meta-iodobenzyl-guanidine ( 123 I-MIBG) myocardial scintigraphy ignores the dynamic response from vesicular...
