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QSAR, pharmacophore modeling and molecular docking studies to identify structural alerts for some nitrogen heterocycles as dual inhibitor of telomerase reverse transcriptase and human telomeric G-quadruplex DNA
BackgroundTelomerase reverse transcriptase (TERT) and human telomeric G-quadruplex DNA are amongst the favorable target for researchers to discover...
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The crosstalk between telomeres and DNA repair mechanisms: an overview to mammalian somatic cells, germ cells, and preimplantation embryos
Telomeres are located at the ends of linear chromosomes and play a critical role in maintaining genomic stability by preventing premature activation...
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Potential effects of assisted reproductive technology on telomere length and telomerase activity in human oocytes and early embryos
Telomeres are repetitive DNA sequences at eukaryotic chromosome ends and function in maintaining genome integrity and stability. These unique...
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RNA modifications: importance in immune cell biology and related diseases
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization,...
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Nucleolin Mediates LPS-induced Expression of Inflammatory Mediators and Activation of Signaling Pathways
In this study, we investigated the effects of nucleolin on lipopolysaccharide (LPS)-induced activation of MAPK and NF-KappaB (NF-κB) signaling...
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Action mechanisms and research methods of tRNA-derived small RNAs
tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), are small regulatory RNAs processed from mature...
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The biological applications of DNA nanomaterials: current challenges and future directions
DNA, a genetic material, has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology in...
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Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere...
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Novel therapeutic protocol in the research of breast cancer treatment - Targeting the border
The complex signaling pathways and interactions inside and among cells which are responsible for the appearance and evolving of malignancy have a...
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Study protocol: a randomised controlled trial of the effects of a multi-modal exercise program on cognition and physical functioning in older women
BackgroundIntervention studies testing the efficacy of cardiorespiratory exercise have shown some promise in terms of improving cognitive function in...
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Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene
This study examined the effect of astilbin on the proliferation of rat aortic smooth muscle cells (RASMCs) induced by angiotensin II (AngII) and...
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Molecular surveillance of drug-resistant Plasmodium falciparum in two distinct geographical areas of Nigeria
Drug resistance against P. falciparum has been recognized as the crucial obstacle to curbing mortality and morbidity from malaria. We therefore...