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Retinol binding protein 4 and type 2 diabetes: from insulin resistance to pancreatic β-cell function
Background and aimRetinol binding protein 4 (RBP4) is an adipokine that has been explored as a key biomarker of type 2 diabetes mellitus (T2DM) in...
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4-Hydroxyphenyl Retinamide Preferentially Targets FLT3 Mutated Acute Myeloid Leukemia via ROS Induction and NF-κB Inhibition
FMS-like tyrosine kinase 3 (FLT3) mutation is strongly associated with poor prognosis in acute myeloid leukemia (AML). Though many FLT3 inhibitors...
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A Review of Current and Future Management of Geographic Atrophy
Age-related macular degeneration (AMD) is a multifactorial disease and a leading cause of vision impairment in elderly people in Western society....
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Over-expression of LRIG1 suppresses biological function of pituitary adenoma via attenuation of PI3K/AKT and Ras/Raf/ERK pathways in vivo and in vitro
Pituitary adenomas (PAs) are well known as a common intracranial benign tumor, and a portion of PAs are refractory to current therapeutic methods....
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Hypoxia-induced autophagy contributes to radioresistance via c-Jun-mediated Beclin1 expression in lung cancer cells
Reduced radiosensitivity of lung cancer cells represents a pivotal obstacle in clinical oncology. The hypoxia-inducible factor (HIF)-1α plays a...
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The role of targeted therapies in the management of progressive glioblastoma
Question What is the influence of targeted medical therapies on disease control and survival in the adult patient with progressive glioblastoma?
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Impact of 4HPR on the expression of E-Cad in human bladder transitional epithelial cancer cells T24
Previous researches showed that the expression level of E-Cad in most infiltrating cancer cells was reduced or negative. This study explored whether...
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The association of altered RARβ gene expression with the cervical lesion pathogenesis
ObjectivePrevious reports have shown that the gene promoter region of retinoic acid receptor β (RARβ) was hypermethylated in cervical carcinoma,...
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Serum retinol binding protein 4 level is related with renal functions in Type 2 diabetes
Aim : We aimed to evaluate the metabolic parameters and diabetes complications which would probably affect the serum retinol-binding protein 4 (RBP4)...
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Biological therapy for pediatric malignancy: Current perspectives
Biologicals are defined as agents that are either uniquely or partially tumor-specific. Great expectations were raised by the success in agents that...
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Risk-reduction surgery in BRCA mutation carriers in a Spanish population: adherence and results
ObjectiveTo analyse the level of adherence to prophylactic surgery of breast and/or ovarian cancer in female carriers of the BRCA1 or BRCA2 mutation...
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Microarray analysis of thapsigargin — induced stress to the endoplasmic reticulum of mouse osteoblasts
Activating transcription factor 4 (ATF4) protein has a dual role in osteoblasts. It functions as a responder to stress to the endoplasmic reticulum...
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A Phase I Clinical and Pharmacokinetic Study of Fenretinide Combined with Paclitaxel and Cisplatin for Refractory Solid Tumors
Background : Fenretinide is a semi-synthetic retinoid that has pro-apoptotic effects as a single agent and synergistically with chemotherapy in vitro ....
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Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists
The anti-cancer activities and toxicities of retinoic acid (RA) and synthetic retinoids are mediated through nuclear RA receptors (RARs) and retinoid...
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Phase II trial of fenretinide in advanced renal carcinoma
Purpose : Fenretinide, a synthetic form of retinoid, induced apoptosis even in chemotherapy resistant cell lines. A phase II study was hence conducted...