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Evaluation of hTERT, KRT7, and survivin in urine for noninvasive detection of bladder cancer using real‐time PCR
BackgroundTransitional cell carcinoma (TCC) of the bladder is the second most common genitourinary malignancy. Because of the low sensitivity of...
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Comparison of Four Protocols for In Vitro Differentiation of Human Embryonic Stem Cells into Trophoblast Lineages by BMP4 and Dual Inhibition of Activin/Nodal and FGF2 Signaling
Human embryonic stem cells (hESCs) cultured in media containing bone morphogenic protein 4 (BMP4; B) differentiate into trophoblast-like cells....
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Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer
Gastric cancer (GC) is one of the most common malignant tumors in the world, and it is also the third largest cause of cancer-related death in the...
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Prognostic assessment capability of a five-gene signature in pancreatic cancer: a machine learning based-study
BackgroundA prognostic assessment method with good sensitivity and specificity plays an important role in the treatment of pancreatic cancer...
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A prognostic model based on immune-related long noncoding RNAs for patients with epithelial ovarian cancer
BackgroundLong noncoding RNAs (lncRNAs) are important regulators of gene expression and can affect a variety of physiological processes. Recent...
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Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course
BackgroundCatenin (Cadherin-Associated Protein), Beta 1 ( CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations...
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Molecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum
Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case...
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Heterotopia of salivary gland tissue in the pancreas
Heterotopia of the salivary gland occurs mainly in the head and neck region of the human body, rarely in regions such as the rectum, but has never...
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Bile level of cytokeratin 7 as a diagnostic marker for cholangiocarcinoma: a case-control study in Egyptian patients
BackgroundCholangiocarcinoma (CCA) is an aggressive malignancy with a poor prognosis of less than 20% five-year survival rate. Early diagnosis is...
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Extraskeletal myxoid chondrosarcoma of the gingival: a rare case report and review of the literature
BackgroundExtraskeletal myxoid chondrosarcoma (EMC) is a rare malignant tumor described in the head and neck region, especially in the gingival. We...
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Deep learning and transfer learning identify breast cancer survival subtypes from single-cell imaging data
BackgroundSingle-cell multiplex imaging data have provided new insights into disease subtypes and prognoses recently. However, quantitative models...
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EWSR1-PATZ1 fusion renal cell carcinoma: a recurrent gene fusion characterizing thyroid-like follicular renal cell carcinoma
Thyroid-like follicular renal cell carcinoma is an uncommon kidney tumor with no distinct molecular alteration described to date. This cohort of...
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Identification of adenoid subtype characterized with immune-escaped phenotype in lung squamous carcinoma based on transcriptomics
Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and its demarcation contributes to various therapeutic outcomes. However, a small...
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Small molecule inhibitors targeting m6A regulators
As the most common form of epigenetic regulation by RNA, N 6 methyladenosine (m 6 A) modification is closely involved in physiological processes, such...
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ALK-rearranged renal cell carcinoma with TPM3::ALK gene fusion and review of the literature
ALK-rearranged renal cell carcinoma (ALK-RCC) is a very rare novel molecularly defined entity in the recently published fifth edition of the World...
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Mechanisms and pathophysiology of Barrett oesophagus
Barrett oesophagus, in which a metaplastic columnar mucosa that can predispose individuals to cancer development lines a portion of the distal...
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ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions
Cell plasticity sustains intra-tumor heterogeneity and treatment resistance in melanoma. Deciphering the transcriptional mechanisms governing...
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Adenoid Cystic Carcinoma of Cervix: A Rare Entity
BackgroundAdenoid cystic carcinoma is a malignant neoplasm rarely occurring in the uterine cervix. It accounts for less than 1% of all cervical...
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Fusobacterium Nucleatum Is a Risk Factor for Metastatic Colorectal Cancer
ObjectiveIncreasing evidence has indicated that there is a correlation between Fusobacterium nucleatum ( F. nucleatum ) abundance and poor prognosis...
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MOB kinase activator 1A acts as an oncogene by targeting PI3K/AKT/mTOR in ovarian cancer
BackgroundTo illuminate the precise roles of MOB Kinase Activator 1 A (MOB1A) in the development of ovarian cancer (OC).
MethodsMOB1A expression and...