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Reassessing the Role of Ischemia Imaging: Insights from the ISCHEMIA Trial
Ischemia imaging plays an important role in prognostication as well as guiding decision for revascularization with known CAD, as shown in multiple...
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Triglyceride-glucose index is associated with myocardial ischemia and poor prognosis in patients with ischemia and no obstructive coronary artery disease
BackgroundIschemia and no obstructive coronary artery disease (INOCA) is increasingly recognized and associated with poor outcomes. The...
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Systematic Review of Literature Citing the ISCHEMIA Trial
Purpose of ReviewOptimal therapy for patients with chronic coronary artery disease (CCD) has long been a topic under investigation and a subject of...
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Acute Mesenteric Ischemia Involving the Colon
Acute mesenteric ischemia is a surgical emergency with dismal prognosis. Its management consists of prompt diagnosis with expedite surgery. The...
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Myocardial motion in acute ischemia: revealing invisible deformation by echocardiography
Echocardiography has been used clinically to assess regional myocardial wall motion for the diagnosis of acute myocardial ischemia or stress-induced...
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Gastric ischemia as an under-reported cause of death in older people
Acute gastric ischemia is a rare condition due to the rich vascular supply of the stomach. Here we present a case of fatal gastric ischemia...
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Neutrophil extracellular traps induced by IL-1β promote endothelial dysfunction and aggravate limb ischemia
Vascular inflammation and endothelial dysfunction contribute to vascular diseases. While neutrophil extracellular traps (NETs) participate in some...
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The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemia–reperfusion injury caused...
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Association of prediabetes with clinical outcomes in patients with chronic coronary syndrome: a post hoc analysis of the ISCHEMIA and ISCHEMIA-CKD trials
BackgroundThere is conflicting evidence whether prediabetes is associated with adverse clinical outcomes in patients with chronic coronary syndrome....
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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited...
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Delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage- areas at risk
Delayed cerebral ischemia is a major neurological complication of aneurysmal subarachnoid hemorrhage. Its unpredictable course and potentially...
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Evaluation of renal ischemia–reperfusion injury using CEUS in mice
BackgroundRenal ischemia–reperfusion injury (IRI) frequently occurs clinically. We investigated the value of contrast-enhanced ultrasonography (CEUS)...
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Unilateral upper and lower limb ischemia mimics stroke: a case report
BackgroundAlthough stroke and acute limb ischemia seem easily distinguishable by anamnesis and physical examination, symptoms may overlap and...
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Recurrent syncope due to ischemia with non-obstructive coronary artery disease: a case report
BackgroundIschemia with non-obstructive coronary artery disease is a prevalent form of ischemic heart disease. The majority of ischemia with...
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Management of penile post-circumcision ischemia by pentoxifylline infusion and hyperbaric oxygen therapy
BackgroundPost-circumcision penile ischemia is a devastating complication. We will present our experience in managing children with various forms of...
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Cardioprotective Strategies After Ischemia–Reperfusion Injury
Acute myocardial infarction (AMI) is associated with high morbidity and mortality worldwide. Although early reperfusion is the most effective...
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Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine
Liver ischemia-reperfusion injury (LIRI) is a pathological process involving multiple injury factors and cell types, with different stages....
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The Role of P53 in Myocardial Ischemia-Reperfusion Injury
PurposeP53 is one of the key tumor suppressors. In normal cells, p53 is maintained at low levels by the ubiquitination of the ubiquitinated ligase...
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Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia–reperfusion: role of TSPO and STAR
Hypercholesterolemia is a major risk factor for coronary artery diseases and cardiac ischemic events. Cholesterol per se could also have negative...
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Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion-induced ferroptosis via the keap1/Nrf2/GPX4 signaling pathway
BackgroundGinsenoside Rg3 is a component of ginseng that protects against myocardial ischemia/reperfusion (MI/R) injury. Ferroptosis is a new form of...
