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Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, synovium, and adipose...
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Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
BackgroundTumor eradication is one of the most important challengeable categories in oncological studies. In this account, besides the molecular...
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Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Activation of gasdermin D (GSDMD) and its concomitant cardiomyocyte pyroptosis are critically involved in multiple cardiac pathological conditions....
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Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases
Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the physiology of organ viability and in the pathophysiology of...
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Biomimetic microneedles: exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins
BackgroundDespite its popularity, acceptability, and convenience, the oral route is not the classical route for the administration of all critical...
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Effect of decalcification protocols on immunohistochemistry and molecular analyses of bone samples
Diagnosis of osteocartilaginous pathologies depends on morphological examination and immunohistochemical and molecular biology analyses....
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Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac
BackgroundActinium-225 ( 225 Ac, t 1/2 = 9.9 d) is a promising candidate radionuclide for use in targeted alpha therapy (TAT), though the currently...
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Hematology and serum biochemistry values in greylag geese (Anser anser) in Southeast Iran
Greylag geese ( Anser anser ) migrate to the different parts of Iran including Sistan region, southeastern Iran. It breeds in Hamun lake in Sistan...
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Mass spectrometry imaging: a novel technology in rheumatology
Mass spectrometry imaging (MSI) is used to determine the relative abundance and spatial distribution of biomolecules such as peptides, proteins,...
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Hyperparathyroid crisis presenting with hyperemesis gravidarum
PurposePrimary hyperparathyroidism during pregnancy is a rare condition, and the diagnosis may be confounded by pregnancy related conditions. Since...
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Mass Spectrometry Imaging, an Emerging Technology in Neuropsychopharmacology
Mass spectrometry imaging is a powerful tool for directly determining the distribution of proteins, peptides, lipids, neurotransmitters, metabolites...
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Calcium Citrate and Vitamin D in the Treatment of Osteoporosis
The combination of calcium with vitamin D (vitamin D 3 [colecalciferol]) forms the basis of preventive and therapeutic regimens for osteoporosis. A...
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Adolescent and adult risk factors for testicular cancer
The incidence of testicular cancer has been increasing over the past several decades in many developed countries. The reasons for the increases are...
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Patient-to-Patient Variability in Autologous Pericardial Matrix Scaffolds for Cardiac Repair
The pursuit of alternate therapies for end-stage heart failure post-myocardial infarction has led to the development of a variety of in situ gelling...
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Effect of matrine on HepG2 cells: role of glutathione and cytochrome c
ObjectiveTo investigate the death mode of human hepatoma cells exposed to matrine and the role of glutathione (GSH) and cytochrome c.
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Structural characterziation of pollen allergens
The molecular characterization of allergens has accelerated significantly since the wide-spread implementation of modern analytical methods. The...
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Intestinal transport of an obdurate anion: oxalate
In this review, we focus on the role of gastrointestinal transport of oxalate primarily from a contemporary physiological standpoint with an emphasis...
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Radioprotectors
1. Cytoprotection, using radioprotectors, is mandatory to improve the therapeutic ratio of RT and RCT.
2. The ideal radioprotector needs to have a...