Search
Search Results
-
A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children
BackgroundProcedural sedation and analgesia are commonly used in the Emergency Departments. Despite this common need, there is still a lack of...
-
Comparative Evaluation of Intranasal Dexmedetomidine Spray Versus Intranasal Normal Saline Spray in Patients Undergoing Transalveolar Extractions for Anxiety Reduction: A Randomized Control Study
BackgroundDexmedetomidine has dose-dependent selectivity for alpha 2 adrenoceptors. It is a good sedative with analgesic characteristics and good...
-
Efficacy and safety of intranasal midazolam versus intranasal ketamine as sedative premedication in pediatric patients: a meta-analysis of randomized controlled trials
BackgroundIntranasal midazolam and ketamine have been widely used as sedative premedication in children. It is difficult to determine which one...
-
Intranasal dexmedetomidine and intranasal ketamine association allows shorter induction time for pediatric sedation compared to intranasal dexmedetomidine and oral midazolam
BackgroundNon-painful diagnostic procedures require an inactive state for a prolonged time, so that sedation is often needed in younger children to...
-
Predictors of pediatric sedation failure with initial dose of intranasal dexmedetomidine and oral midazolam
BackgroundTo assess the sedative failure rate over different dose combinations of intranasal dexmedetomidine and oral midazolam for procedural...
-
Intranasal insulin for COVID-19-related smell loss
BackgroundQuantitative (hyposmia and anosmia) and qualitative (phantosmia and parosmia) olfactory disorders are common consequences of COVID-19...
-
Intranasal analgesia for acute moderate to severe pain in children – a systematic review and meta-analysis
BackgroundChildren in acute pain often receive inadequate pain relief, partly from difficulties administering injectable analgesics. A rapid-acting,...
-
Comparison on the Effectiveness and Safety of Transseptal Suturing Versus Intranasal Splints After Septoplasty: A Systematic Review and Meta-analysis
BackgroundThe application of transseptal suturing as an alternative to intranasal splints in preventing postoperative complications, such as...
-
Efficacy and safety of intranasal ketamine compared with intranasal dexmedetomidine as a premedication before general anesthesia in pediatric patients: a systematic review and meta-analysis of randomized controlled trials
PurposeTo compare the efficacy and safety of intranasal ketamine with intranasal dexmedetomidine as a premedication in pediatric patients undergoing...
-
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the effectiveness of currently licensed SARS-CoV-2 vaccines based on...
-
Intranasal oxytocin in a genetic animal model of autism
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders mainly characterized by deficient sociability and repetitive behaviors....
-
Median effective dose of esketamine for intranasal premedication in children with congenital heart disease
BackgroundEsketamine is commonly used as a premedication for its sedation effect. However, the proper dosage for intranasal use in children with...
-
Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam
BackgroundThe exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging...
-
Effects of different doses of intranasal dexmedetomidine on related complications and parents’ satisfaction in anesthetized children: a systematic review
BackgroundAgitation/delirium is commonly seen in children after anesthesia, and a proper dose of dexmedetomidine can prevent this complication. This...
-
The effect of age on outpatient pediatric procedural sedation with intranasal dexmedetomidine and oral midazolam
AbstractProcedural sedation for diagnostic examination is a common practice in children. The study aims to analyze the sedative effect and safety of...
-
Oral midazolam vs. intranasal dexmedetomidine plus oral midazolam for sedation of pediatric outpatients: a double-blinded randomized controlled trial
BackgroundModerate to deep sedation is required for dental treatment of children with dental anxiety. Midazolam is the most commonly used sedative,...
-
Efficacy and Tolerability of Intranasal Midazolam Administration for Antiseizure Treatment in Adults: A Systematic Review
ObjectiveThe objective of this study was to assess the efficacy and tolerability of intranasal midazolam (in-MDZ) administration for antiseizure...
-
Efficacy and safety of intranasal agents for the acute treatment of migraine: a systematic review and network meta-analysis
BackgroundIntranasal agents may be ideal for the treatment of migraine patients. Many new acute intranasal-specific therapies have been developed,...
-
Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety
Short-hairpin RNAs (shRNA), targeting knockdown of specific genes, hold enormous promise for precision-based therapeutics to treat numerous...
-
Intranasal Dexmedetomidine for Pain Management in Older Patients: A Cross-Over, Randomized, Double-Blinded, Active-Controlled Trial
BackgroundDaily care procedures provoke breakthrough pain and anxiety in palliative situations. Dexmedetomidine may be an alternative to opioids...
