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The 2022 International League Against Epilepsy Classification and Definition of Childhood Epilepsy Syndromes: An Update for Pediatricians
The 2017 classification of the epilepsies of International League Against Epilepsy (ILAE) defined three diagnostic levels, including seizure type,...
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Consensus on pediatric epilepsy surgery for young children: an investigation by the China Association Against Epilepsy task force on epilepsy surgery
Researchers have widely acknowledged the therapeutic value of epilepsy surgery for drug-resistant epilepsy. Nonetheless, there is a substantial gap...
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The efficacy and safety of patent Foramen Ovale Closure for Refractory Epilepsy (PFOC-RE): a prospectively randomized control trial of an innovative surgical therapy for refractory epilepsy patients with PFO of high-grade right-to-left shunt
BackgroundA significant proportion of patients with epilepsy have an unknown etiology and lack effective targeted therapeutic drugs. Patent Foramen...
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Absence seizures in lesion-related epilepsy
BackgroundIn the new International League Against Epilepsy (ILAE) classification of seizure types, generalized seizures such as absence seizures...
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Further advances in epilepsy
In 2017, one of us reviewed advances in epilepsy (Manford in J Neurol 264:1811–1824, 2017). The current paper brings that review up to date and gives...
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Protocol for the development of an international Core Outcome Set for treatment trials in adults with epilepsy: the EPilepsy outcome Set for Effectiveness Trials Project (EPSET)
BackgroundA Core Outcome Set (COS) is a standardised list of outcomes that should be reported as a minimum in all clinical trials. In epilepsy, the...
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Epilepsy in Asian countries
Epilepsy affects 50 million people worldwide. Nearly 80% of people with epilepsy live in resource-constrained low-income and middle-income countries....
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The influence of genetics on epilepsy syndromes in infancy and childhood
Genetics is rapidly evolving and is actively playing a role in how we diagnose and manage epilepsy. The definition of an epilepsy syndrome has...
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Clinical risk factors related to post-stroke epilepsy patients in Indonesia: a hospital-based study
BackgroundStroke had been accounted to cause almost 50% of epilepsy in the elderly and may lead to poor functional outcomes. Many studies examining...
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Drug resistant epilepsy and associated factors among children with epilepsies in Tanzania: a cross-sectional study
BackgroundEpilepsy contributes to high morbidity among children and adolescents in develo** countries. A quarter of all children with epilepsy will...
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The impact of referring patients with drug-resistant focal epilepsy to an epilepsy center for presurgical diagnosis
BackgroundEpilepsy surgery is an established treatment for drug-resistant focal epilepsy (DRFE) that results in seizure freedom in about 60% of...
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School performance and psychiatric comorbidity in juvenile absence epilepsy and juvenile myoclonic epilepsy: a Danish population-based cohort study
BackgroundWe aimed to determine school performance and psychiatric comorbidity in juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME),...
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Exploring the Smoking-Epilepsy Nexus: a systematic review and meta-analysis of observational studies
BackgroundEpilepsy, characterized by recurrent unprovoked seizures, poses significant challenges to affected individuals globally. While several...
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Immune Mechanisms in Epileptogenesis: Update on Diagnosis and Treatment of Autoimmune Epilepsy Syndromes
Seizures and epilepsy can result from various aetiologies, yet the underlying cause of several epileptic syndromes remains unclear. In that regard,...
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Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed
BackgroundThere is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of...
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A multicenter, matched case–control analysis comparing burden of illness among patients with tuberous sclerosis complex related epilepsy, generalized idiopathic epilepsy, and focal epilepsy in Germany
BackgroundDepending on the underlying etiology and epilepsy type, the burden of disease for patients with seizures can vary significantly. This...
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Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy
BackgroundThe study is aimed to identify the predictors of Quality of Life (QOL) in women with epilepsy (WWE) on carbamazepine (CBM) and...
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Regulation of Keap1-Nrf2 axis in temporal lobe epilepsy—hippocampal sclerosis patients may limit the seizure outcomes
BackgroundAccumulation of reactive oxygen species (ROS) exacerbates neuronal loss during seizure-induced excitotoxicity. Keap1 (Kelch-like...
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Effectiveness and tolerability of brivaracetam in patients with epilepsy stratified by comorbidities and etiology in the real world: 12-month subgroup data from the international EXPERIENCE pooled analysis
ObjectiveTo assess the effectiveness and tolerability of brivaracetam (BRV) in adults with epilepsy by specific comorbidities and epilepsy etiologies.
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Cerebral small vessel disease increases risk for epilepsy: a Mendelian randomization study
BackgroundDespite previous research suggesting a potential association between cerebral small vessel disease (CSVD) and epilepsy, the precise...
