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Use of complementary and alternative medicine in children affected by oncologic, neurologic and liver diseases: a narrative review
Complementary and alternative medicine (CAM) consist of a broad group of restorative resources often linked to existing local cultures and...
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Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs
BackgroundEpilepsy is a neurological disease that requires long-term antiepileptic drugs (AEDs). The old generation of AEDs may affect serum...
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Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review
Cannabidiol, a non-intoxicating phytocannabinoid, has potential therapeutic effects over a broad range of disorders. Recently, there has been...
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Carbamazepine regulates USP10 through miR-20a-5p to affect the deubiquitination of SKP2 and inhibit osteogenic differentiation
BackgroundAntiepileptic drugs (AEDs) harm bone health and are significantly associated with osteoporosis development. In this study, we aimed to...
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Evaluation and Treatment of Adult Status Epilepticus in the Emergency Department
Purpose of ReviewThis review summarizes the current knowledge and evidence behind the diagnosis and management of adult status epilepticus (SE) in...
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Relationship between Attention Deficit Hyperactivity Disorder and epilepsy: a literature review
BackgroundAttention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurological disorder. ADHD has been linked to epilepsy.
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Effect of long-term administration of clonazepam, carbamazepine, and valproate on cognitive, psychological, and personality changes in adult epilepsy: a case–control study
BackgroundEpilepsy can be treated with antiepileptic drugs (AEDs) which may have psychiatric and behavioral side effects. Additionally, the...
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Hypomyelination caused by a novel homozygous pathogenic variant in FOLR1: complete clinical and radiological recovery with oral folinic acid therapy and review of the literature
BackgroundNeurodegeneration due to cerebral folate transport deficiency is a rare autosomal recessive disorder caused by biallelic pathogenic...
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Analysis of treatment adherence and cost among patients with epilepsy: a four‐year retrospective cohort study in Pakistan
BackgroundThe adherence pattern of antiepileptic drugs (AEDs) among patients with epilepsy is relatively lower in the United States and different...
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Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues
Purpose of ReviewIn this review, we discuss the mechanism of action of gabapentinoids and the potential consequences of long-term treatment with...
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Calculation and management of ketogenic diet parenteral nutrition in super-refractory status epilepticus
Super-refractory status epilepticus (SRSE) is an important neurological emergency associated with high mortality and morbidity and poses a heavy...
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Psychomotor function in children with epilepsy seen at a tertiary hospital in southern Nigeria: does treatment with anti-epileptic drugs have any effect?
BackgroundPsychomotor slowing is more commonly reported in children with epilepsy (CWE) compared to healthy controls. The effect of anti-epileptic...
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Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis
BackgroundLacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of...
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Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations
Due to the diverse mechanisms of action of antiseizure drugs, there has been a rise in prescriptions of these drugs for non-epileptic pathologies....
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Genetic analysis of developmental and epileptic encephalopathy caused by novel biallelic SZT2 gene mutations in three Chinese Han infants: a case series and literature review
BackgroundDevelopmental and epileptic encephalopathy (DEE) exhibits phenotypic and genetic heterogeneity. Biallelic variants of the SZT2 gene can...
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Sturge–Weber syndrome: an update for the pediatrician
BackgroundSturge–Weber syndrome (SWS) is a rare congenital neurocutaneous disorder characterized by the simultaneous presence of both cutaneous and...
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The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials
BackgroundDravet Syndrome (DS) is a rare and severe form of childhood epilepsy that is often refractory to conventional antiepileptic drugs. Emerging...
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Management of antiepileptic drug–induced nutrition-related adverse effects
Although antiepileptic drugs (AEDs) are mainstay of the treatment of epilepsy, they are associated with significant adverse effects. The present...
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Ischemic and Thrombotic Events Associated with Concomitant Xa-inhibiting Direct Oral Anticoagulants and Antiepileptic Drugs: Analysis of the FDA Adverse Event Reporting System (FAERS)
IntroductionFactor Xa-inhibiting direct oral anticoagulants (FXa-DOACs) undergo hepatic metabolism via cytochrome P-450 (CYP450). Concomitant use of...
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Sturge-Weber syndrome: an update on the relevant issues for neurosurgeons
PurposeSturge-Weber syndrome (SWS) is a neurocutaneous facomatosis characterized by facial and leptomeningeal angioma, glaucoma, seizures, and...
