Search
Search Results
-
Develo** generic templates to shape the future for conducting integrated research platform trials
BackgroundInterventional clinical studies conducted in the regulated drug research environment are designed using International Council for...
-
On the use of non-concurrent controls in platform trials: a sco** review
BackgroundPlatform trials gained popularity during the last few years as they increase flexibility compared to multi-arm trials by allowing new...
-
The European & Develo** Countries Clinical Trials Partnership (EDCTP) Knowledge Hub: develo** an open platform for facilitating high-quality clinical research
There is stark global inequity in health research in terms of where studies happen, who leads the research and the ultimate beneficiaries of the...
-
Meta-research on pragmatism of randomized trials: rationale and design of the PragMeta database
BackgroundPragmatic trials provide decision-oriented, real-world evidence that is highly applicable and generalizable. The interest in real-world...
-
A genderful research world: rapid review, design, and pilot study of an interactive platform for curated sex and gender health research resources
BackgroundIntegration of sex and gender into health research is best practice for designing and conducting equitable, rigorous scientific research....
-
Protocol for co-producing a framework and integrated resource platform for engaging patients in laboratory-based research
BackgroundPatient engagement in research is the meaningful and collaborative interaction between patients and researchers throughout the research...
-
A review of research on eligibility criteria for clinical trials
The purpose of this paper is to systematically sort out and analyze the cutting-edge research on the eligibility criteria of clinical trials....
-
The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies
The German Centre for Cardiovascular Research (DZHK) is one of the German Centres for Health Research and aims to conduct early and...
-
Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO)
BackgroundCommunity-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired...
-
The sinking platform test: a novel paradigm to measure persistence in animal models
Persistence is the propensity to maintain goal-directed actions despite adversities. While this temperamental trait is crucial to mitigate depression...
-
The future of clinical trials—goals, ideas, and discussion
Clinical trials are subject to an ever-evolving landscape of treatment options, regulatory requirements, socioeconomic conditions, and paradigms of...
-
Successes and lessons learned in database development for national multi-site cancer care delivery research trials: the Alliance for Clinical Trials in Oncology experience
IntroductionAlliance for Clinical Trials in Oncology (Alliance) coordinated trials utilize Medidata Rave® (Rave) as the primary clinical data capture...
-
Operational complexity versus design efficiency: challenges of implementing a phase IIa multiple parallel cohort targeted treatment platform trial in advanced breast cancer
BackgroundPlatform trial designs are used increasingly in cancer clinical research and are considered an efficient model for evaluating multiple...
-
MatchMiner: an open-source platform for cancer precision medicine
Widespread, comprehensive sequencing of patient tumors has facilitated the usage of precision medicine (PM) drugs to target specific genomic...
-
Development of an integrated and comprehensive clinical trial process management system
BackgroundThe process of initiating and completing clinical drug trials in hospital settings is highly complex, with numerous institutional,...
-
National Preclinical Sepsis Platform: develo** a framework for accelerating innovation in Canadian sepsis research
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical...
-
Registering transparency: the making of the international clinical trial registry platform by the world health organization (2004–2006)
BackgroundThis paper examines the events and conditions that led to the creation of the International Clinical Trials Registry Platform (ICTRP) in...
-
Develo** a core outcome set for assessing clinical safety outcomes of cardiovascular diseases in clinical trials of integrated traditional Chinese medicine and Western medicine: study protocol
BackgroundIntegrative medicine is commonly used in China. Researchers prefer to report efficacy outcomes rather than safety outcomes in clinical...
-
Moving towards vertically integrated artificial intelligence development
Substantial interest and investment in clinical artificial intelligence (AI) research has not resulted in widespread translation to deployed AI...
-
HIV HGM biobank as a research platform for paediatric infectious diseases and COVID-19 pandemic
AimThe initial cases of COVID-19 appeared in December 2019 and Spain was one of the most affected countries during the first wave (March to June)....
