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Blood and sputum eosinophilia in COPD exacerbation
BackgroundExacerbations in chronic obstructive pulmonary disease (COPD) are major contributors to worsening lung function, impaired quality of life,...
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Exploration of induced sputum BIRC3 levels and clinical implications in asthma
BackgroundBaculoviral IAP repeat-containing 3 (BIRC3) which encodes a member of the IAP family of proteins upregulated in the asthma expression...
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Bronchial eosinophils, neutrophils, and CD8 + T cells influence asthma control and lung function in schoolchildren and adolescents with severe treatment-resistant asthma
BackgroundStudies in adult severe treatment-resistant asthma (STRA) have demonstrated heterogeneous pathophysiology. Studies in the pediatric age...
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Transcriptomic responses in the blood and sputum of cigarette smokers compared to e-cigarette vapers
RationaleElectronic (e)-cigarettes are popular among youth and cigarette smokers attempting to quit. Studies to date have focused on the utility of...
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Fractional exhaled nitric oxide and eosinophil count in induced sputum to guide the management of children with asthma: a cost-utility analysis
IntroductionPrevious evidence has shown that fractional exhaled nitric oxide (FeNO) and eosinophil count in induced sputum (EO) are cost-effective...
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Transcriptome analysis of sputum cells reveals two distinct molecular phenotypes of “asthma and chronic obstructive pulmonary disease overlap” in the elderly
BackgroundLittle is known about the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO). This study examined the...
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Monitoring COPD patients: systemic and bronchial eosinophilic inflammation in a 2-year follow-up
BackgroundHigh blood eosinophils seem to predict exacerbations and response to inhaled corticosteroids (ICS) treatment in patients with chronic...
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Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
BackgroundExtracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data...
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Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults
BackgroundDifferences between adult patients with severe early-onset and late-onset asthma have not been well studied.
ObjectivesTo determine the...
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Different Impacts of Blood and Sputum Eosinophil Counts on Lung Function and Clinical Outcomes in Asthma: Findings from the COREA Cohort
PurposeBlood (EOS-B) and sputum (EOS-S) eosinophil counts may contribute differently to asthma pathogenesis. We compared the impact of the baseline...
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Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0
BackgroundTo date, most studies involving high-throughput analyses of sputum in asthma and COPD have focused on identifying transcriptomic signatures...
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Underestimation of airway luminal eosinophilia by quantitative sputum cytometry
RationaleOn Wright-stained sputum cytospins, eosinophil differential of ≥ 1.2% is considered abnormal, and ≥ 2.3% identifies an eosinophilic...
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Decreased TLR7 expression was associated with airway eosinophilic inflammation and lung function in asthma: evidence from machine learning approaches and experimental validation
BackgroundAsthma is a global public health concern. The underlying pathogenetic mechanisms of asthma were poorly understood. This study aims to...
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Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes
BackgroundThere is a need to identify the asthma inflammatory phenotypes of patients to facilitate personalized asthma treatment. Sputum induction is...
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Different expression levels of interleukin-36 in asthma phenotypes
Interleukin (IL)-36 family is closely associated with inflammation and consists of IL-36α, IL-36β, IL-36γ, and IL-36Ra. The role of IL-36 in the...
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An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
BackgroundAsthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in develo** drugs that...
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Chronic air pollution-induced subclinical airway inflammation and polygenic susceptibility
BackgroundAir pollutants can activate low-grade subclinical inflammation which further impairs respiratory health. We aimed to investigate the role...
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Domiciliary monitoring of exhaled nitric oxide in the management of asthma: a pilot study
BackgroundWhether asthma patients could benefit from home monitoring for fractional exhaled nitric oxide (flow of 50 mL/s, Fe NO50 ) is unknown. We...
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Biomarker-guided withdrawal of inhaled corticosteroids in asthma patients with a non-T2 inflammatory phenotype – a randomized controlled trial study protocol
BackgroundNon-T2 asthma is characterized by the absence of elevated type 2 inflammatory biomarkers such as blood-eosinophils, total and...
