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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs...
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A resource of induced pluripotent stem cell (iPSC) lines including clinical, genomic, and cellular data from genetically isolated families with mood and psychotic disorders
Genome-wide (GWAS) and copy number variant (CNV) association studies have reproducibly identified numerous risk alleles associated with bipolar...
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Growth rates of human induced pluripotent stem cells and neural stem cells from attention-deficit hyperactivity disorder patients: a preliminary study
Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental polygenic disorder that affects more than 5% of children and adolescents...
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Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages
Macrophages play a role in nephrolithiasis, offering the possibility of develo** macrophage-mediated preventive therapies. To establish a system...
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Induced Pluripotent Stem Cell–Based Modeling of Single-Ventricle Congenital Heart Diseases
Purpose of ReviewCongenital heart disease includes a wide variety of structural cardiac defects, the most severe of which are single ventricle...
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Modeling Nonischemic Genetic Cardiomyopathies Using Induced Pluripotent Stem Cells
Purpose of ReviewThe advent of induced pluripotent stem cells (iPSC) has paved the way for new in vitro models of human cardiomyopathy. Herein, we...
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Modeling tuberous sclerosis complex with human induced pluripotent stem cells
BackgroundTuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder with a birth incidence of 1:6000 in the United States that is...
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Opportunities and limitations for studying neuropsychiatric disorders using patient-derived induced pluripotent stem cells
Neuropsychiatric disorders affect a large proportion of the global population and there is an urgent need to understand the pathogenesis and to...
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PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells
BackgroundBase editing via CRISPR-Cas9 has garnered attention as a method for correcting disease-specific mutations without causing double-strand...
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Chenodeoxycholic acid rescues axonal degeneration in induced pluripotent stem cell-derived neurons from spastic paraplegia type 5 and cerebrotendinous xanthomatosis patients
BackgroundBiallelic mutations in CYP27A1 and CYP7B1 , two critical genes regulating cholesterol and bile acid metabolism, cause cerebrotendinous...
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Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells
The degeneration of nigral (A9) dopaminergic (DA) neurons causes motor symptoms in Parkinson’s disease (PD). We use small-molecule compounds to...
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Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration
Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of...
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Hair-follicle-associated pluripotent (HAP) stem cells differentiate into mature beating cardiomyocyte sheets on flexible substrates in vitro
Cardiomyocytes have been differentiated from various stem cells such as human embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC),...
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Generation of muscle progenitors from human-induced pluripotent stem cells
BackgroundSmall molecules have a role in the differentiation of human-induced pluripotent stem cells (hiPSCs) into different cell linages. The aim of...
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Iris-derived induced pluripotent stem cells that express GFP in all somatic cells of mice and differentiate into functional retinal neurons
When regenerated tissue is generated from induced pluripotent stem cells (iPSCs), it is necessary to track and identify the transplanted cells....
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Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells
NMDA receptors (NMDARs), a prominent subtype of glutamatergic receptors, are implicated in the pathogenesis and development of neuropsychiatric...
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PTCH1-null induced pluripotent stem cells exclusively differentiate into immature ectodermal cells with large areas of medulloblastoma-like tissue
Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder with an increased incidence of tumors, such as basal cell carcinomas...
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Modeling Cardiac SARS-CoV-2 Infection with Human Pluripotent Stem Cells
AbstractAlthough SARS-CoV-2, the causative virus of the global COVID-19 pandemic, primarily affects the respiratory tract, it is now recognized to...
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Comparison of gene expression between human and mouse iPSC-derived cardiomyocytes for stem cell therapies of cardiovascular defects via bioinformatic analysis
BackgroundPreclinical studies have demonstrated the potential use of induced pluripotent stem cells (iPSCs) to treat cardiovascular disease (CVD). In...
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Membrane remodelling triggers maturation of excitation–contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes
The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) for cardiac regenerative medicine strongly depends on...
