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Analysing cluster randomised controlled trials using GLMM, GEE1, GEE2, and QIF: results from four case studies
BackgroundUsing four case studies, we aim to provide practical guidance and recommendations for the analysis of cluster randomised controlled trials.
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Statistical analysis of publicly funded cluster randomised controlled trials: a review of the National Institute for Health Research Journals Library
BackgroundIn cluster randomised controlled trials (cRCTs), groups of individuals (rather than individuals) are randomised to minimise the risk of...
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Study protocol for ELders AT Ease (ELATE): a cluster randomised controlled trial of cognitive behaviour therapy to reduce depressive symptoms in aged care residents
BackgroundThis protocol describes a study of the effectiveness of cognitive behaviour therapy (CBT) for reducing depressive symptoms in older adults...
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Trial protocol for the Building Resilience through Socio-Emotional Training (ReSET) programme: a cluster randomised controlled trial of a new transdiagnostic preventative intervention for adolescents
BackgroundAdolescence is a period of heightened vulnerability to develo** mental health problems, and rates of mental health disorder in this age...
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Systematic review of the characteristics of school-based feasibility cluster randomised trials of interventions for improving the health of pupils in the UK
BackgroundThe last 20 years have seen a marked increase in the use of cluster randomised trials (CRTs) in schools to evaluate interventions for...
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Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long COVID: protocol for the LISTEN randomised controlled trial
BackgroundIndividuals living with long COVID experience multiple, interacting and fluctuating symptoms which can have a dramatic impact on daily...
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Bayesian statistics in the design and analysis of cluster randomised controlled trials and their reporting quality: a methodological systematic review
BackgroundIn a cluster randomised controlled trial (CRCT), randomisation units are “clusters” such as schools or GP practices. This has...
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LessStress - how to reduce stress in school: evaluation of a universal stress prevention in schools: study protocol of a cluster-randomised controlled trial
BackgroundChronic stress is detrimental to health, and children and young people have had to cope with significantly more stress since the start of...
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Clustering of continuous and binary outcomes at the general practice level in individually randomised studies in primary care - a review of 10 years of primary care trials
BackgroundIn randomised controlled trials, the assumption of independence of individual observations is fundamental to the design, analysis and...
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Peer-led recovery groups for people with psychosis in South Africa (PRIZE): protocol for a randomised controlled feasibility trial
BackgroundThe available care for people with psychosis in South Africa is inadequate to support personal recovery. Group peer support interventions...
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Mental health specialist video consultations versus treatment as usual in patients with depression or anxiety disorders in primary care: study protocol for an individually randomised superiority trial (the PROVIDE-C trial)
BackgroundMost people with mental disorders, including those with severe and chronic disorders, are treated solely by their general practitioner...
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Effectiveness and cost-effectiveness of an intervention to improve Initial Medication Adherence to treatments for cardiovascular diseases and diabetes in primary care: study protocol for a pragmatic cluster randomised controlled trial and economic model (the IMA-cRCT study)
BackgroundBetween 2 and 43% of patients who receive a new prescription in PC do not initiate their treatments. Non-initiation is associated with...
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The Reflective Fostering Programme—improving the wellbeing of children in care through a group intervention for foster carers: a randomised controlled trial
BackgroundThe needs of children in care are a government priority, yet the evidence base for effective interventions to support the emotional...
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Balance Right in Multiple Sclerosis (BRiMS): a feasibility randomised controlled trial of a falls prevention programme
BackgroundBalance, mobility impairments and falls are problematic for people with multiple sclerosis (MS). The “Balance Right in MS (BRiMS)”...
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Trial of remote continuous versus intermittent NEWS monitoring after major surgery (TRaCINg): a feasibility randomised controlled trial
BackgroundDespite medical advances, major surgery remains high risk with up to 44% of patients experiencing postoperative complications. Early...
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Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs)
BackgroundPeople need high-quality information to make decisions about research participation. Providing information in written format alone is...
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The multimorbidity collaborative medication review and decision making (MyComrade) study: a pilot cluster randomised trial in two healthcare systems
BackgroundWhile international guidelines recommend medication reviews as part of the management of multimorbidity, evidence on how to implement...
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The importance of transdiagnostic symptom level assessment to understanding prognosis for depressed adults: analysis of data from six randomised control trials
BackgroundDepression is commonly perceived as a single underlying disease with a number of potential treatment options. However, patients with major...
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A systematic review to determine the effect of strategies to sustain chronic disease prevention interventions in clinical and community settings: study protocol
BackgroundThe primary purpose of this review is to synthesise the effect of strategies aiming to sustain the implementation of evidenced-based...
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Differentiated prevention and care to reduce the risk of HIV acquisition and transmission among female sex workers in Zimbabwe: study protocol for the ‘AMETHIST’ cluster randomised trial
BackgroundFemale sex workers (FSW) in sub-Saharan Africa are disproportionately affected by HIV and are critical to engage in HIV prevention, testing...
