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Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches
Hesperetin is one of the prominent flavonoids found in citrus fruit. Several research studies have reported that hesperetin can promote vasodilation...
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In vivo translocator protein in females with autism spectrum disorder: a pilot study
Sex-based differences in the prevalence of autism spectrum disorder (ASD) are well-documented, with a male-to-female ratio of approximately 4:1. The...
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Corneal nerves and amyotrophic lateral sclerosis: an in vivo corneal confocal imaging study
ObjectivesAmyotrophic lateral sclerosis (ALS) is a severe motor neuron disorder. Diagnosis is challenging due to its clinical heterogeneity and the...
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Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs
The objective of this study was to synthesize and characterize pharmaceutical characteristics of florfenicol sustained-release granules (FSRGs) in...
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In vivo study of newly developed albumin-conjugated urate oxidase for gout treatment
BackgroundExogenously providing engineered Uox with enhanced half-life is one of the important urate-lowering treatments for gout. The potential of...
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A feasibility study of in vivo quantitative ultra-short echo time-MRI for detecting early cartilage degeneration
ObjectivesTo explore the feasibility of Ultra-short echo time (UTE) – MRI quantitative imaging in detecting early cartilage degeneration in vivo and...
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Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models
Diabetic retinopathy (DR), one of the leading causes of visual impairment and blindness worldwide, is one of the major microvascular complications in...
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Correlation of ex vivo and in vivo ammonia production with L-asparaginase biological activity in adults with lymphoid malignancies
Silent inactivation of L-asparaginase (L-Asp) represents rapid clearance of L-Asp by anti-L-Asp IgG antibodies without clinical symptoms. Measurement...
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In Vivo Models for the Study of Hyaluronic Acid Fillers: A Review
BackgroundHyaluronic acid (HA) filler application is one of the most frequent minimally invasive aesthetic procedures used worldwide. Its properties...
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An in vivo study to investigate an original intramedullary bone graft harvesting technology
BackgroundHarvesting bone graft (BG) from the intramedullary canal to treat bone defects is largely conducted using the Reamer–Irrigator–Aspirator...
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Objective Noninvasive Measurement of the Volumizing Effect of a Dermal Filler: An In Vivo Study
BackgroundInformation about the volumizing effects of dermal fillers is critical for physicians’ understanding of product features and prudent...
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Corneal nerve changes in herpes zoster ophthalmicus: a prospective longitudinal in vivo confocal microscopy study
PurposeTo study the changes in corneal nerves and corneal sensitivity over a 6-month period in patients with herpes zoster ophthalmicus (HZO)...
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In vitro and in vivo study on the treatment of non-small cell lung cancer with radionuclide labeled PD-L1 nanobody
PurposeNanobodies have become promising carriers due to excellent in vivo properties. Radiopharmaceutical therapy targeting programmed cell death...
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The combined anti-tumor effects of 5-fluorouracil and neurokinin receptor inhibitor, aprepitant, against colorectal cancer: In vitro and in vivo study
BackgroundColorectal cancer (CRC) is one of the world’s largest health concerns with growing global incidence and mortality. The potential value of...
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Intrarenal pressure study using 7.5 French flexible ureteroscope with or without ureteral access sheath in an ex-vivo porcine kidney model
Introduction7.5F digital fURS and 9.5/11.5F ureteral access sheaths (UAS), both conventional (cUAS) and vacuum-assisted (vaUAS), are commercially...
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Brainstem anatomy with 7-T MRI: in vivo assessment and ex vivo comparison
BackgroundThe brainstem contains grey matter nuclei and white matter tracts to be identified in clinical practice. The small size and the low...
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Robotic-assisted versus laparoscopic bowel anastomoses: randomized crossover in vivo experimental study
BackgroundInitial learning curves are potentially shorter in robotic-assisted surgery (RAS) than in conventional laparoscopic surgery (LS). There is...
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Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy
BackgroundThere is room for improvement of prevention of venous thromboembolism (VTE) after lower-leg cast application or knee arthroscopy....
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A retrospective study using machine learning to develop predictive model to identify urinary infection stones in vivo
Preoperative diagnosis of urinary infection stones is difficult, and accurate detection of stone composition can only be performed ex vivo. To...
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Kidney dynamic SPECT acquisition on a CZT swiveling-detector ring camera: an in vivo pilot study
BackgroundLarge field of view CZT SPECT cameras with a ring geometry are available for some years now. Thanks to their good sensitivity and high...
