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A case of progressive multifocal leukoencephalopathy in a post-kidney transplant patient with improvement after discontinuation of immunosuppressive drugs and combination therapy with mefloquine and mirtazapine
BackgroundProgressive multifocal leukoencephalopathy is a rare disease, but the prognosis is very poor, especially in the immunosuppressed state with...
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Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive...
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Identification of cytokine-predominant immunosuppressive class and prognostic risk signatures in glioma
PurposeThe advent of immune checkpoint blockade (ICB) therapies this year has changed the way glioblastoma (GBM) is treated. Meanwhile, some patients...
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Prevention of Hepatitis B Reactivation in Patients Receiving Immunosuppressive Therapy: a Case Series and Appraisal of Society Guidelines
Hepatitis B (HBV) reactivation (HBVr) is a potentially fatal complication in patients with past HBV exposure receiving immunosuppressive therapy....
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Determinants of immunosuppressive therapy in renal transplant recipients: an Italian observational study (the CESIT project)
BackgroundVery scanty evidence is available on factors influencing the choice of immunosuppressive drug therapy after kidney transplantation.
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How immunosuppressive drugs may directly target podocytes in glomerular diseases
Podocytes are the direct target of immunologic injury in many immune-mediated glomerular diseases, leading to proteinuria and subsequent kidney...
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Shifting cold to hot tumors by nanoparticle-loaded drugs and products
Cold tumors lack antitumor immunity and are resistant to therapy, representing a major challenge in cancer medicine. Because of the immunosuppressive...
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Plasmablastic lymphoma occurring in ulcerative colitis during treatment with immunosuppressive therapy
A 53-year-old man who had a history of ulcerative colitis (UC) for 2 years underwent colonoscopy as regular follow-up. The results showed an elevated...
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Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study
BackgroundExcept in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive...
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Position statement on infection screening, prophylaxis, and vaccination of pediatric patients with rheumatic diseases and immunosuppressive therapies, part 3: precautions in situations of surgery, fever, and opportunistic infections
The objective of this study is to provide practical recommendations on the management of pediatric patients with immune-mediated rheumatic diseases...
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FBP1 is a potential prognostic biomarker and correlated with tumor immunosuppressive microenvironment in glioblastoma
Hypoxia has been shown to contribute to tumor immunosuppressive microenvironment and is an effective prognostic indicator. This study aimed to screen...
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DDOST is associated with tumor immunosuppressive microenvironment in cervical cancer
Evidence has revealed that DDOST plays an important role in cancer development and progression. However, there are no reports on functions of DDOST...
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Effect of immunosuppressive medication on postoperative complications following abdominal surgery in Crohn’s disease patients
BackgroundImmunosuppressants represent an effective pharmacological treatment for the remission and management of Crohn’s disease (CD); however, it...
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Outcomes of Escalating Immunosuppressive Treatments for Recalcitrant Noninfectious Posterior Scleritis
IntroductionThis article aimed to summarize the outcomes of escalating immunosuppressive treatments for patients with recalcitrant noninfectious...
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Immunomodulatory and immunosuppressive drug protocols in the treatment of canine primary immune thrombocytopenia, a sco** review
Primary immune thrombocytopenia (ITP) is a cause of severe thrombocytopenia in dogs. Immunosuppressive corticosteroid drugs are frequently used in...
