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COVID-19 vaccine–induced immune thrombotic thrombocytopenia: pathophysiology and diagnosis
Coronavirus disease-19 (COVID-19) vaccine–induced immune thrombotic thrombocytopenia (VITT) is a rare but serious clinical condition with high...
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Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction...
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Diagnosis of immune pathophysiology in patients with bone marrow failure
Differential diagnosis of pancytopenia with bone marrow (BM) hypoplasia represented by aplastic anemia (AA) is often challenging for physicians,...
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The multiple roles of nerve biopsy in the diagnosis and prognosis of suspected immune neuropathies
IntroductionThe value of a sural nerve biopsy for the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is controversial....
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Establishment of a novel glycolysis-immune-related diagnosis gene signature for endometriosis by machine learning
PurposeThe objective of this study was to investigate the key glycolysis-related genes linked to immune cell infiltration in endometriosis and to...
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Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Since their introduction into clinical practice a decade ago, immune checkpoint inhibitors (ICIs) have had an overwhelming impact on cancer...
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Exploration of the combined role of immune checkpoints and immune cells in the diagnosis and treatment of ankylosing spondylitis: a preliminary study immune checkpoints in ankylosing spondylitis
ObjectiveImmune checkpoints have emerged as promising therapeutic targets for autoimmune diseases. However, the specific roles of immune checkpoints...
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Hyperinflammatory syndrome in a paediatric patient with a recent diagnosis of HIV/AIDS infection: hemophagocytic lymphohistiocytosis or immune reconstitution syndrome?
IntroductionHaemophagocytic lymphohistiocytosis is a rare and life-threatening condition caused by uncontrolled immune activation leading to...
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Multidisciplinary recommendations for essential baseline functional and laboratory tests to facilitate early diagnosis and management of immune-related adverse events among cancer patients
Immune checkpoint inhibitors (ICIs) have fundamentally changed the treatment landscape of various cancers. While ICI treatments result in improved...
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Maternal and fetal outcomes of pregnancy occurring after a diagnosis of immune-mediated thrombotic thrombocytopenic purpura
Pregnancy is a well-established trigger for a first episode or relapse of immune thrombotic thrombocytopenic purpura (iTTP). Other outcomes of...
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Improved predictability of pancreatic ductal adenocarcinoma diagnosis using a blood immune cell biomarker panel developed from bulk mRNA sequencing and single-cell RNA-sequencing
BackgroundPancreatic ductal adenocarcinoma (PDAC) remains a devastating cancer due to its poor survival rate, early detection, and resectability....
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Challenges in the diagnosis and management of immune-mediated necrotising myopathy (IMNM) in a patient on long-term statins
Immune-mediated necrotising myopathy (IMNM) is a severe and poorly understood complication of statin use. Prompt management with immunosuppressive...
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The search for a unifying diagnosis involving neurological, endocrine and immune dysfunction: a case report of a novel presentation of DAVID syndrome
BackgroundWe report a novel presentation of deficit in anterior pituitary function with variable immune deficiency (DAVID) syndrome in a healthy...
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Immune Mechanisms in Epileptogenesis: Update on Diagnosis and Treatment of Autoimmune Epilepsy Syndromes
Seizures and epilepsy can result from various aetiologies, yet the underlying cause of several epileptic syndromes remains unclear. In that regard,...
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A ferroptosis-related signature predicts the clinical diagnosis and prognosis, and associates with the immune microenvironment of lung cancer
Targeting ferroptosis-related pathway is a potential strategy for treatment of lung cancer (LC). Consequently, exploration of ferroptosis-related...
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Centrosome amplification-related signature correlated with immune microenvironment and treatment response predicts prognosis and improves diagnosis of hepatocellular carcinoma by integrating machine learning and single-cell analyses
BackgroundCentrosome amplification is a well-recognized oncogenic driver of tumor initiation and progression across a variety of malignancies and has...
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Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy
Tropomyosin has been identified as the major cross-reactive shellfish allergen, but recent studies showed the presence of other clinically relevant...
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Monocytic myeloid-derived suppressor cells as an immune indicator of early diagnosis and prognosis in patients with sepsis
BackgroundImmunosuppression is a leading cause of septic death. Therefore, it is necessary to search for biomarkers that can evaluate the immune...
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Etiology and outcome of non-immune hydrops fetalis in relation to gestational age at diagnosis and intrauterine treatment
ObjectiveTo determine the etiology and outcome of non-immune hydrops fetalis (NIHF) according to gestational age at diagnosis and intrauterine...