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Advances in Immune Tolerance Induction in Enzyme Replacement Therapy
Inborn errors of metabolism (IEMs) are a group of genetic diseases that occur due to the either deficiency of an enzyme involved in a...
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Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6
Helicobacter pylori ( H. pylori, Hp ) has been designated a class I carcinogen and is closely associated with severe gastric diseases. During...
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Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites
BackgroundPatients with rheumatoid arthritis (RA) showed impaired immune tolerance characterized by reduced follicular regulatory T (Tfr) cells, and...
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Clinical characteristics of immune tolerance after pediatric liver transplantation
BackgroundClinical operational tolerance is the ultimate goal for liver transplantation. This study aimed to investigate the clinical characteristics...
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The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells
N6-methyladenosine (m6A) modification is involved in diverse immunoregulation, while the relationship between m6A modification and immune tolerance...
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The Effects of Treatment with Icariin on Immune Tolerance in the Recurrent Spontaneous Abortion Mice
Recurrent spontaneous abortion (RSA) is the most common pregnancy-related complication, affecting 1–5% of pregnancies. Currently, immune imbalance at...
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Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions
Coeliac disease is an autoinflammatory condition caused by immune reactions to cereal gluten proteins. Currently, the only available treatment for...
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Assessing the value of bypassing agent therapy used prophylactic versus on-demand, during immune tolerance induction for treatment of inhibitors: a retrospective chart review
BackgroundHaemophilia A is a bleeding disorder caused by deficiency of coagulation factor VIII (FVIII) which leads to severe and repeated bleedings....
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Textbook of Allergen Tolerance
Allergies are a significant health issue, yet few books exist on allergen tolerance of separation; here the author classifies allergen tolerance...
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Longitudinal profiling of anti-factor VIII antibodies in Japanese patients with congenital hemophilia A during factor VIII replacement and immune-tolerance induction therapy
When patients with hemophilia A develop factor VIII (FVIII) inhibitors, FVIII replacement therapy becomes ineffective. Although immune-tolerance...
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The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses
Purpose of ReviewImmunoglobulin A (IgA) mediates immune exclusion of antigens in the gut. Notably, IgA plays also a role in the prevention of...
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Biomarkers of immune tolerance in kidney transplantation: an overview
Kidney failure, one of the most prevalent diseases in the world and with increasing incidence, is associated with substantial morbidity and...
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The Role of Innate Immune Cells in Allergen Immunotherapy
Purpose of reviewAllergic diseases have become a major health challenge across the world in recent years. Allergen immunotherapy (AIT) is the only...
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Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation
Many inborn errors of immunity (IEI) manifest with hallmarks of both immunodeficiency and immune dysregulation due to uncontrolled immune responses...
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Immune checkpoint inhibitors and cancer immunotherapy by aptamers: an overview
Efforts in cancer immunotherapy aim to counteract evasion mechanisms and stimulate the immune system to recognise and attack cancer cells...
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mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review
Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19...
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Progress in xenotransplantation: overcoming immune barriers
A major limitation of organ allotransplantation is the insufficient supply of donor organs. Consequently, thousands of patients die every year while...
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Bifidobacteria modulate immune response in pediatric patients with cow’s milk protein allergy
BackgroundIn children with an allergy to cow’s milk proteins (CMA), the altered composition of intestinal microbiota influences the immune tolerance...
