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Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance
BackgroundFor sudden infant death syndrome (SIDS), an impaired immunocompetence has been discussed for a long time. Cytokines and chemokines are...
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Rivaroxaban attenuates neutrophil maturation in the bone marrow niche
Pharmacological inhibition of factor Xa by rivaroxaban has been shown to mediate cardioprotection and is frequently used in patients with, e.g.,...
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Effect of ovarian growth factors on ultra-structural maturation in frozen human immature oocytes after in vitro maturation: a comparative study
BackgroundIn artificial reproductive technique (ART), nearly 20% of human oocytes are immature in the germinal vesicle (GV) phase. Consequently, the...
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Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation
The CD39-CD73–adenosinergic pathway converts adenosine triphosphate (ATP) to adenosine for inhibiting anti-tumor immune responses. Therefore,...
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Temperature impacts the bovine ex vivo immune response towards Mycoplasmopsis bovis
Although cattle are the mammalian species with most global biomass associated with a huge impact on our planet, their immune system remains poorly...
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Advances in Immune Tolerance Induction in Enzyme Replacement Therapy
Inborn errors of metabolism (IEMs) are a group of genetic diseases that occur due to the either deficiency of an enzyme involved in a...
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Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate
STING is a pivotal mediator of effective innate and adaptive anti-tumor immunity; however, intratumoral administration of STING agonists have shown...
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Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation
Many inborn errors of immunity (IEI) manifest with hallmarks of both immunodeficiency and immune dysregulation due to uncontrolled immune responses...
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Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation
Bi-directional communication between cumulus cells and the surrounded oocytes is important for the development and functions of both compartments....
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Immune mechanisms in the pathophysiology of hypertension
Hypertension is a leading risk factor for morbidity and mortality worldwide. Despite current anti-hypertensive therapies, most individuals with...
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How does age determine the development of human immune-mediated arthritis?
Does age substantially affect the emergence of human immune-mediated arthritis? Children do not usually develop immune-mediated articular...
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Harnessing innate immune pathways for therapeutic advancement in cancer
The innate immune pathway is receiving increasing attention in cancer therapy. This pathway is ubiquitous across various cell types, not only in...
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Comprehensive analysis of immune cell landscapes revealed that immune cell ratio eosinophil/B.cell.memory is predictive of survival in sepsis
BackgroundImmune dysregulation is a feature of sepsis. However, a comprehensive analysis of the immune landscapes in septic patients has not been...
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Innate Immune Responses in Transplant Immunity
Purpose of ReviewDespite a significant decrease in the rate of acute rejection, long-term solid organ allotransplant success is limited by chronic...
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Immune landscape and response to oncolytic virus-based immunotherapy
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target...
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Immune landscape and immunotherapy of hepatocellular carcinoma: focus on innate and adaptive immune cells
Hepatocellular carcinoma (HCC) is responsible for roughly 90% of all cases of primary liver cancer, and the cases are on the rise. The treatment of...
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Targeting the innate immune system in pediatric and adult AML
While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult...
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Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
BackgroundRadionuclide molecular imaging can be used to visualize the expression levels of molecular targets. Affibody molecules, small and high...
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Role of m6A modifications in immune evasion and immunotherapy
RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N 6 -methyladenosin...
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Emerging mechanisms of obesity-associated immune dysfunction
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus, cardiovascular disease, hypertension and nonalcoholic...
