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Management and treatment of severe immune-related hepatotoxicity based on clinical and pathological characteristics
BackgroundThe management of severe immune-related hepatotoxicity (irH) needs to be further optimized. This study aims to analyze the clinical...
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Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometry (FCM),...
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Clinical characteristics and prognosis of pancreatitis associated with immune checkpoint inhibitors
Background and objectiveImmune checkpoint inhibitors (ICIs) have shown remarkable efficacy against various cancers in clinical practice. However,...
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TERT mutations-associated alterations in clinical characteristics, immune environment and therapy response in glioblastomas
Objective TERTis the most frequently mutated gene in adult glioblastomas (GBMs) defined by the 2021 World Health Organization classification system....
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Tumor-associated characteristics and immune dysregulation in nasopharyngeal carcinoma under the regulation of m7G-related tumor microenvironment cells
BackgroundNasopharyngeal carcinoma (NPC) is a type of malignant tumor with high morbidity. Aberrant levels of N7-methylguanosine (m7G) are closely...
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Immune characteristics of dedifferentiated retroperitoneal liposarcomas and the reliability of regional samples in evaluating their tumor immune microenvironments
BackgroundTumor immunotherapy is a new treatment breakthrough for retroperitoneal liposarcoma (RPLS), which is highly invasive and has few effective...
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A comprehensive review on immune checkpoint inhibitors induced cardiotoxicity characteristics and associated factors
Newly approved cancer drugs called ICIs have shown remarkable success in improving patient survival rates, but they also have the potential for...
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Systemic immune-inflammation index in dural arteriovenous fistula: a feasible biomarker reflecting its clinical characteristics
PurposeThe systemic immune-inflammation index (SII), a marker of systemic inflammation, can be calculated using peripheral blood tests. Although the...
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Integrative stemness characteristics associated with prognosis and the immune microenvironment in lung adenocarcinoma
BackgroundTo comprehensively analyze the stemness characteristics related to prognosis and the immune microenvironment in lung adenocarcinoma (LUAD).
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Immune characteristics and prognostic implications of mucosal-associated invariant T cells in acute myeloid leukemia
Increasing evidence suggests that mucosal-associated invariant T cells (MAITs) play a crucial role in anti-tumor responses against various cancers....
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Tumor characteristics of dissociated response to immune checkpoint inhibition in advanced melanoma
IntroductionImmune checkpoint inhibition (ICI) has improved patients’ outcomes in advanced melanoma, often resulting in durable response. However,...
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Clinicopathological characteristics and outcomes of lupus nephritis patients with scanty immune depositions in kidney biopsies
BackgroundThe clinicopathological features, outcomes, and pathogenesis of lupus nephritis with scanty immune deposits in the kidney biopsy remain...
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Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
The persistent COVID-19 pandemic since 2020 has brought an enormous public health burden to the global society and is accompanied by various...
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Clinical characteristics of liver injury induced by immune checkpoint inhibitors in patients with advanced biliary tract carcinoma
Immune-related liver injuries are closely associated with the liver’s fundamental state. Patients with advanced biliary tract carcinoma (BTC) have...
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Pathological characteristics and immune microenvironment of SMARCA4-deficient undifferentiated uterine sarcoma
SMARCA4- deficient undifferentiated uterine sarcoma (SDUS) is a highly invasive single-gene malignant tumor caused by mutations in the SMARCA4 gene....
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Construction of HBV-HCC prognostic model and immune characteristics based on potential genes mining through protein interaction networks
ObjectiveTo search for human protein-coding genes related to hepatocellular carcinoma (HCC) in the context of hepatitis B virus (HBV) infection, and...
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Characteristics of blood immune cell profile and their correlation with disease progression in patients infected with HIV-1
BackgroundAntiretroviral therapy (ART) can reduce viral load in individuals infected with human immunodeficiency virus (HIV); however, some...
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A novel DNA methylation-related gene signature for the prediction of overall survival and immune characteristics of ovarian cancer patients
BackgroundOvarian cancer (OC) is one of the most life-threatening cancers affecting women worldwide. Recent studies have shown that the DNA...
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Clinical characteristics and prognostic impact of immune checkpoint inhibitor-associated myocarditis in advanced non-small cell lung cancer
Myocarditis is a rare immune-related adverse events (irAEs) with high mortality rates, with few reports on its clinical characteristics and...
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Bioinformatics analysis of the immune cell infiltration characteristics and correlation with crucial diagnostic markers in pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension (PAH) is a pathophysiological syndrome, characterized by pulmonary vascular remodeling. Immunity and...
