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Immune profile of primary and recurrent epithelial ovarian cancer cases indicates immune suppression, a major cause of progression and relapse of ovarian cancer
BackgroundOvarian cancer is the third most prevalent cancer in Indian women. Relative frequency of High grade serous epithelial ovarian cancer...
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Return to Play After Knee Articular Cartilage Restoration: Surgical Options, Rehabilitation Protocols, and Performance Outcomes
Purpose of ReviewNumerous cartilage restoration techniques have proven to be effective in the treatment of articular cartilage defects. The ultimate...
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Innate immune memory in inflammatory arthritis
The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was observed during the plague of...
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Role of neurotransmitters in immune-mediated inflammatory disorders: a crosstalk between the nervous and immune systems
Immune-mediated inflammatory diseases (IMIDs) are a group of common heterogeneous disorders, characterized by an alteration of cellular homeostasis....
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The maternal gut microbiome in pregnancy: implications for the develo** immune system
The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal...
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Weight cycling based on altered immune microenvironment as a result of metaflammation
As a result of the obesity epidemic, more people are concerned about losing weight; however, weight regain is common, leading to repeated weight loss...
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Incomplete immune reconstitution and its predictors in people living with HIV in Wuhan, China
ObjectiveThis study aimed to build and validate a nomogram model to predict the risk of incomplete immune reconstitution in people living with HIV...
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Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6
Helicobacter pylori ( H. pylori, Hp ) has been designated a class I carcinogen and is closely associated with severe gastric diseases. During...
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FSTL3 is associated with prognosis and immune cell infiltration in lung adenocarcinoma
PurposeFSTL3 expression is altered in various types of cancer. However, the role and mechanism of action of FSTL3 in lung adenocarcinoma development...
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Heterogeneity of the tumor immune microenvironment and clinical interventions
The tumor immune microenvironment (TIME) is broadly composed of various immune cells, and its heterogeneity is characterized by both immune cells and...
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Innate immune responses in pneumonia
The lungs are an immunologically unique environment; they are exposed to innumerable pathogens and particulate matter daily. Appropriate clearance of...
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Beyond Immune Checkpoint Inhibitors: Emerging Targets in Melanoma Therapy
Purpose of reviewThis review provides a comprehensive update on recent advancements in melanoma treatment by highlighting promising therapeutics with...
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Immune dysregulation in multiple myeloma: the current and future role of cell-based immunotherapy
Immune dysregulation is a hallmark of clinically active multiple myeloma (MM). Interactions between malignant clonal cells and immune cells within...
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Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors
The gut microbiota modulates immune processes both locally and systemically. This includes whether and how the immune system reacts to emerging...
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Understanding COVID-19 in children: immune determinants and post-infection conditions
AbstractCoronavirus disease 2019 in children presents with milder clinical manifestations than in adults. On the other hand, the presence of a wide...
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The kinetics of inhibitory immune checkpoints during and post-COVID-19: the knowns and unknowns
The immune system is tightly regulated to prevent immune reactions to self-antigens and to avoid excessive immune responses during and after...
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The combined therapy of miR-383-5p restoration and paclitaxel for treating MDA-MB-231 breast cancer
The deregulation of microRNAs (miRs) has been identified in tumor development. Indeed, the restoration of tumor-suppressive miRs has been associated...
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Surgical Management for Hair Restoration: A Review of Contemporary Techniques
BackgroundHair loss can cause psychological distress for patients, regardless of the etiology or extent of the defect. Many conservative and...
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A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal
Immune checkpoint inhibitors (ICIs) have induced durable clinical responses in a subset of patients with colorectal cancer (CRC). However, the...
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Immune reconstitution, vaccine responses, and rituximab use after ex-vivo CD34-selected myeloablative allogenic hematopoietic cell transplantation
Myeloablative T cell depleted (CD34-selected) hematopoietic cell transplantation (HCT) is associated with less acute and chronic graft versus host...