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Ibuprofen dosing measurement accuracy using infants’ versus children’s ibuprofen: a randomized crossover comparison
BackgroundIbuprofen liquid comes in two pediatric concentrations: 200 mg/5 mL for infants and 100 mg/5 mL for children. This study aimed to...
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Comparing the efficacy of intravenous morphine versus ibuprofen or the combination of ibuprofen and acetaminophen in patients with closed limb fractures: a randomized clinical trial
IntroductionThis study aims to investigate the effectiveness of intravenous ibuprofen or intravenous ibuprofen plus acetaminophen compared to...
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Early Treatment of Patent Ductus Arteriosus with Ibuprofen
The Baby-OSCAR trial is a multicenter, double-blinded, randomized, placebo-controlled trial conducted to evaluate if ‘early selective treatment’ of...
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Vascular and pulmonary effects of ibuprofen on neonatal lung development
BackgroundIbuprofen is a nonsteroidal anti-inflammatory drug that is commonly used to stimulate closure of a patent ductus arteriosus (PDA) in very...
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Is Expectant Management Noninferior to Early Ibuprofen for Patent Ductus Arteriosus?
In this multicentre non-inferiority trial, 273 infants with echocardiographically confirmed PDA (diameter >1.5 mm) who were extremely preterm (<28...
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Intravenous ibuprofen versus ketorolac for perioperative pain control in open abdominal hysterectomy: a randomized controlled trial
BackgroundWe aimed to compare the analgesic effects of intravenous ibuprofen to ketorolac after open abdominal hysterectomy.
MethodsThis randomized...
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Increasing the dose of ibuprofen with postnatal age to close a hemodynamically significant patent ductus arteriosus in very preterm infants
Patent ductus arteriosus (PDA) is associated with neonatal morbidities in high-risk preterm infants. Early neonatal treatment by ibuprofen induces...
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A Multi-Center Evaluation of the Pharmacokinetics and Safety of Intravenous Ibuprofen in Infants 1–6 Months of Age
BackgroundEnteral ibuprofen was first approved as a prescription drug in 1974 for the US market. An intravenous (IV) ibuprofen formulation is...
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Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation
BackgroundThe objective of the present investigation was to obtain directly compressible agglomerates of ibuprofen with nicotinamide by a...
