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Inhibition of TLR7 and TLR9 Reduces Human Cholangiocarcinoma Cell Proliferation and Tumor Development
BackgroundToll-like receptors (TLRs) are key players in innate immunity and modulation of TLR signaling has been demonstrated to profoundly affect...
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Blood-based T cell receptor anti-viral CDR3s are associated with worse overall survival for neuroblastoma
With the advent of large collections of adaptive immune receptor recombination reads representing cancer, there is the opportunity to further...
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The role of toll-like receptors (TLRs) and their therapeutic applications in glomerulonephritis
One of the most important features of innate immunity is the presence of a special group of pattern recognition receptors (PRRs) called toll-like...
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Prevalence and incidence of iron deficiency in European community-dwelling older adults: an observational analysis of the DO-HEALTH trial
Background and aimIron deficiency is associated with increased morbidity and mortality in older adults. However, data on its prevalence and incidence...
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T cells in health and disease
T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and...
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Lymphatic filariasis, infection status in Culex quinquefasciatus and Anopheles species after six rounds of mass drug administration in Masasi District, Tanzania
BackgroundLymphatic filariasis (LF) elimination program in Tanzania started in 2000 in response to the Global program for the elimination of LF by...
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Effects and mechanisms of acupuncture on women related health
Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when...
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Supreme Court 2022: Abortion, Guns, a Leak, and a New Justice
The 2021-2022 Term of the Supreme Court was among the most consequential in modern history. Critical decisions included overturning constitutional...
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Pattern recognition receptors in health and diseases
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of...
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Levels of uPA and PAI-1 in breast cancer and its correlation to Ki67-index and results of a 21-multigene-array
BackgroundConventional parameters including Ki67, hormone receptor and Her2/neu status are used for risk stratification for breast cancer. The serine...
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Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome
This review aimed to focus on the recent progress of the understanding of the role of phosphatidylinositol 3-kinase (PI3K) in polycystic ovary...
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Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex®): A Review in Multiple Sclerosis-Related Spasticity
Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (THC/CBD, Sativex ® , nabiximols) is available in numerous countries worldwide...
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Effectiveness of isoniazid preventative therapy in reducing incidence of active tuberculosis among people living with HIV/AIDS in public health facilities of Addis Ababa, Ethiopia: a historical cohort study
BackgroundHuman Immunodeficiency Virus (HIV) pandemic has exacerbated tuberculosis disease especially in Sub-Saharan African countries. The World...
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The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session
Sponsorship Statement: Publication of this supplement is sponsored by the European Society for Blood and Marrow Transplantation.
Copyright: Modified...