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DHAV 3CD targets IRF7 and RIG-I proteins to block the type I interferon upstream signaling pathway
Duck hepatitis A virus type 1 (DHAV-1) is an acute, highly lethal infectious agent that infects ducklings and causes up to 95% mortality in ducklings...
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Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study
p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast...
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Loss of IRF7 accelerates acute myeloid leukemia progression and induces VCAM1-VLA-4 mediated intracerebral invasion
Interferon regulatory factor 7 (IRF7) is widely studied in inflammatory models. Its effects on malignant progression have been documented mainly from...
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IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
BackgroundCombination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs...
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Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells
BackgroundBoth humoral and cellular immune mechanisms are involved in the onset and progression of autoimmune responses in systemic lupus...
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Aortic smooth muscle TRPV4 channels regulate vasoconstriction in high salt-induced hypertension
Recent studies have focused on the contribution of vascular endothelial transient receptor potential vanilloid 4 (TRPV4) channels to hypertension....
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Decitabine suppresses MDSC-induced immunosuppression through dual functional mechanism and inhibits melanoma metastasis
Myeloid-derived suppressor cells (MDSCs) play a crucial role in promoting melanoma metastasis. Reprogramming MDSCs into mature M1 macrophages has...
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African swine fever virus MGF360-11L negatively regulates cGAS-STING-mediated inhibition of type I interferon production
The type I interferon (IFN-I) signaling pathway is an important part of the innate immune response and plays a vital role in controlling and...
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Characterization of virus-mediated autoimmunity and the consequences for pathological process in patients with systemic lupus erythematosus
Introduction/ObjectivesThis study aimed to identify differentially expressed genes (DEGs) of systemic lupus erythematosus (SLE) using gene...
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The effect of BKV reactivation on cytokines behavior in kidney transplanted patients
BackgroundBK virus associated nephropathy (BKVAN) is one of the common causes of graft loss among kidney transplanted recipients (KTRs). The current...
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Chilblains observed during the COVID-19 pandemic cannot be distinguished from classic, cold-related chilblains
BackgroundType 1 interferon (IFN-I) response induced by SARS-CoV-2 has been hypothesized to explain the association between chilblain lesions (CL)...
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ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis
AbstractToll-like receptors are mutated or overexpressed in up to 50% of patients with myelodysplastic syndrome (MDS). Endogenous retroviruses (ERV)...
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Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER − )...
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Bioinformatics analyses of gene expression profile identify key genes and functional pathways involved in cutaneous lupus erythematosus
BackgroundLupus erythematosus is an autoimmune disease that causes damage to multiple organs ranging from skin lesions to systemic manifestations....
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Functional characterization of goose IRF1 in IFN induction and anti-NDV infection
Interferon regulatory factors (IRFs) play a key role in many aspects of immune response, and IRF1, IRF3, and IRF7 are positive regulators of IFN...
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Host methylation predicts SARS-CoV-2 infection and clinical outcome
BackgroundSince the onset of the SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR
1 . Host epigenome manipulation post coronavirus...
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Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis
BackgroundExcessive type I IFN (IFN-I) production by plasmacytoid dendritic cells (pDCs) promotes autoimmunity. Recently, we reported that a...
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Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications
BackgroundGenetic variation underly inter-individual variation in host immune responses to infectious diseases, and may affect susceptibility or the...
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