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Plasma IL13Rα2 as a novel liquid biopsy biomarker for glioblastoma
PurposeGlioblastoma (GBM) is the most common and deadliest brain tumor with unrelenting and rapid disease progression. The standard of care for GBM...
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IL13Rα2-targeted third-generation CAR-T cells with CD28 transmembrane domain mediate the best anti-glioblastoma efficacy
Chimeric antigen receptor (CAR)-modified T (CAR-T) cell therapy has been proven to be a powerful tool for the treatment of cancer, however, the...
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Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis
BackgroundLung fibrosis is a chronic lung disease with a high mortality rate with only two approved drugs (pirfenidone and nintedanib) to attenuate...
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Novel Clinical Trials and Approaches in the Management of Glioblastoma
Purpose of ReviewThe purpose of this review is to discuss a wide variety of novel therapies recently studied or actively undergoing study in patients...
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Neurotoxicity of Cancer Immunotherapies Including CAR T Cell Therapy
Purpose of ReviewTo outline the spectrum of neurotoxicity seen with approved immunotherapies and in pivotal clinical trials including immune...
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Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive...
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Immuntherapie und zielgerichtete Therapie von Gliomen
The success of immunotherapies for the treatment of extracranial tumors has led to the development of various immune-mediated therapeutic approaches...
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Immuntherapie und zielgerichtete Therapie von Gliomen
The success of immunotherapies for the treatment of extracranial tumors has led to the development of various immune-mediated therapeutic approaches...
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Immunotherapy for pediatric low-grade gliomas
Pediatric low-grade gliomas (pLGGs) are the most common brain tumor types affecting children. Although gross-total resection remains the treatment of...
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Advances in Immunotherapies for Gliomas
Purpose of ReviewImmunotherapy-based treatment of glioblastoma has been challenging because of the tumor’s limited neoantigen profile and weakly...
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Immuntherapie gegen Gliome
BackgroundGliomas represent the most frequent malignant primary brain tumors in adults. Despite multimodal treatment concepts involving surgery,...
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Current approaches in glioblastoma multiforme immunotherapy
Glioblastoma multiform (GBM) is the most prevalent CNS (central nervous system) tumor in adults, with an average survival length shorter than 2 years...
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99mTc-labeled peptide targeting interleukin 13 receptor α 2 for tumor imaging in a cervical cancer mouse model
ObjectivePep-1 (CGEMGWVRC) can potently bind to interleukin 13 receptor α 2 (IL-13Rα2), a tumor-restricted receptor found to be expressed in various...
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Characterization and Treatment of Spinal Tumors
The prevalence of spinal tumors is rare in comparison to brain tumors which encompass most central nervous system tumors. Tumors of the spine can be...
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Advances in Treatment of Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastomas
Purpose of ReviewThe management of isocitrate dehydrogenase (IDH)-wildtype glioblastomas is an area of unmet need. Despite multimodal therapy...
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Molecular imaging of cellular immunotherapies in experimental and therapeutic settings
Cell-based cancer immunotherapies are becoming a routine part of the armamentarium against cancer. While remarkable successes have been seen,...
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Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes,...
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From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress
Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in terms of therapeutic resistance, and poor survival...
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The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
BackgroundThe beneficial effect of fibre intake on reducing the risk of gastric cancer (GC) has been emphasized in recent years; however, the...