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The IL-23–IL-17 pathway as a therapeutic target in axial spondyloarthritis
The cytokines IL-23 and IL-17 have an important role in the pathogenesis of, and as a therapeutic target in, both animal models of chronic...
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The Current Clinical Trial Landscape for Hidradenitis Suppurativa: A Narrative Review
Hidradenitis suppurativa (HS) is a skin disease resulting from chronic, recurrent inflammation around hair follicles, characterized by...
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Effects of the IL-23–IL-17 pathway on bone in spondyloarthritis
Over the past several years, a pathophysiological role for the IL-23–IL-17 pathway in human disease has been defined. A subset of rheumatic diseases,...
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Effect of guselkumab on serum biomarkers in patients with active psoriatic arthritis and inadequate response to tumor necrosis factor inhibitors: results from the COSMOS phase 3b study
BackgroundGuselkumab is a selective interleukin (IL)-23 inhibitor targeting the IL-23p19 subunit. In the phase 3b COSMOS trial, guselkumab...
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Identification of key functional pathways: arginine biosynthesis and IL-17 signalling in placental decidua of unexplained recurrent pregnancy loss through RNA sequencing—a case series
BackgroundThree or more consecutive pregnancy losses before the 20th week of gestation constitute recurrent pregnancy loss (RPL), and about half of...
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Deucravacitinib for the Treatment of Psoriatic Disease
Psoriasis is an immune-mediated disease, with the interleukin (IL)-23/IL-17 axis currently considered its main pathogenic pathway. Tyrosine kinase 2...
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Generalized Pustular Psoriasis in Pregnancy: Current and Future Treatments
Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin disease characterized by sudden widespread eruption of sterile pustules with...
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Targeting the IL-23/IL-17 Pathway in Psoriasis: the Search for the Good, the Bad and the Ugly
New promising treatments have been developed for psoriasis that target different parts of the interleukin (IL)-23/IL-17 pathway. This approach is...
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A Review of the Clinical Trial Landscape in Psoriasis: An Update for Clinicians
As our understanding of the pathogenesis of psoriasis has evolved over the past two decades, so has the number of treatment options. The introduction...
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Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients
Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated...
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Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling
BackgroundDiverse signalling pathways are involved in carcinogenesis and one of such pathways implicated in many cancers is the interleukin 6/signal...
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Genetic variants in IL-17A rs10484879 and serum levels of IL-17A are associated with psoriasis risk
Psoriasis is an inflammatory skin disease characterized by keratinocyte hyperproliferation with effective environmental and genetic factors. Recent...
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Treatment Options and Goals for Patients with Generalized Pustular Psoriasis
Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin disorder characterized by sudden widespread eruption of superficial sterile...
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Transcriptome analysis of immune cells from Behçet’s syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet’s syndrome
BackgroundBehçet’s syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms....
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Pustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options
Pustular psoriasis is an unusual form of psoriasis that frequently presents clinical challenges for dermatologists. The condition presents with...
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Quantitative proteomic screening uncovers candidate diagnostic and monitoring serum biomarkers of ankylosing spondylitis
BackgroundWe sought to discover serum biomarkers of ankylosing spondylitis (AS) for diagnosis and monitoring disease activity.
Methods ...
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The role of interleukin (IL)-23 in regulating pain in arthritis
Current understanding of IL-23 biology, with its link to other pro-inflammatory cytokines, for example, IL-17 and granulocyte macrophage-colony...
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Treatment of Juvenile Spondyloarthritis: Where We Stand
Juvenile spondyloarthritis is a subset of juvenile idiopathic arthritis (JIA) with onset in late childhood and adolescence and a strong association...
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JAK Inhibitors for Treatment of Psoriasis: Focus on Selective TYK2 Inhibitors
Despite advances in the treatment of psoriasis, there is an unmet need for effective and safe oral treatments. The Janus Kinase–Signal Transducer and...
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Systemic Treatment of Psoriasis with JAK Inhibitors: A Review
Psoriasis is a prevalent chronic inflammatory disease. The inflammatory response is driven by T cells and mediated by multiple cytokines such as...
