Search
Search Results
-
Interleukin 18 and IL-18 BP response to Sars-CoV-2 virus infection
The immune response to the SARS-CoV-2 infection is crucial to the patient outcome. IL-18 is involved in the lymphocyte response to the disease and it...
-
Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
BackgroundDivergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms....
-
SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has...
-
Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case–control study
The exact immunological mechanisms of post infectious bronchiolitis obliterans (PIBO) in childhood are not fully known. It has been shown that the...
-
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
BackgroundSeveral inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by...
-
Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy
BackgroundImpulsivity is a transdiagnostic feature linked to severe clinical expression and a potential target for psychopharmacological strategies....
-
Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity
Background and aimsObesity predisposes to metabolic and cardiovascular diseases. Adipose tissue inflammation and systemic inflammation contribute to...
-
Remifentanil upregulates hepatic IL-18 binding protein (IL-18BP) expression through transcriptional control
Interleukin (IL)-18 plays an important role in liver ischemia/reperfusion (I/R) injury. We have previously demonstrated that remifentanil protects...
-
Biological and clinical roles of IL-18 in inflammatory diseases
Several new discoveries have revived interest in the pathogenic potential and possible clinical roles of IL-18. IL-18 is an IL-1 family cytokine with...
-
The 4th NextGen therapies of SJIA and MAS, part 4: it is time for IL-18 based trials in systemic juvenile idiopathic arthritis?
Since IL-18 has recently emerged as a biomarker associated with refractory disease course in SJIA, the focus of the discussion was the feasibility of...
-
Mouse models of systemic juvenile idiopathic arthritis and macrophage activation syndrome
Macrophage activation syndrome (MAS) is a life-threatening complication of pediatric rheumatic diseases, occurring most commonly in children with...
-
Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis
BackgroundOne of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in...
-
Hepatitis A virus infection
Hepatitis A is a vaccine-preventable infection caused by the hepatitis A virus (HAV). Over 150 million new infections of hepatitis A occur annually....
-
Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study
BackgroundSepsis is a heterogeneous syndrome due to a variable range of dysregulated processes in the host immune response. Efforts are made to...
-
NLRP3 Inflammasome: a Novel Insight into Heart Failure
AbstractAmong numerous cardiovascular diseases, heart failure is a final and fatal stage, and its morbidity, mortality, and rehospitalization rate...
-
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses...
-
Adult-Onset Still’s Disease (AOSD): Advances in Understanding Pathophysiology, Genetics and Emerging Treatment Options
Adult-onset Still’s disease (AOSD) is a multisystemic complex disorder clinically characterised by episodes of spiking fever, evanescent rash,...
-
Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation
BackgroundInterleukin-1 receptor antagonists can reduce mortality in septic shock patients with hepatobiliary dysfunction and disseminated...
-
Beyond Immune Checkpoint Inhibitors: Emerging Targets in Melanoma Therapy
Purpose of reviewThis review provides a comprehensive update on recent advancements in melanoma treatment by highlighting promising therapeutics with...
-
Linking Genetic Diagnosis to Therapeutic Approach in Very Early Onset Inflammatory Bowel Disease: Pharmacologic Considerations
Very early onset inflammatory bowel disease (VEO-IBD) is diagnosed in children < 6 years of age, and in rare cases may be due to an identifiable...