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Targeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases
Lung metastases are the primary cause of death for osteosarcoma (OS) patients. We recently validated interleukin-11 receptor α (IL-11Rα) as a...
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IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
BackgroundPulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in...
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Bone–fat linkage via interleukin-11 in response to mechanical loading
Positive regulators of bone formation, such as mechanical loading and PTH, stimulate and negative regulators, such as aging and glucocorticoid...
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New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
IL-6 family cytokines are defined by the common use of the signal-transducing receptor chain glycoprotein 130 (gp130). Increasing evidence indicates...
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Switchable CAR T cell strategy against osteosarcoma
Immunotherapy with chimeric antigen receptor T (CAR T) cells has changed the treatment of hematological malignances, but they are still a challenge...
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The Role of Interleukins in the Pathogenesis of Dermatological Immune-Mediated Diseases
Autoimmune inflammatory diseases are primarily characterized by deregulated expression of cytokines, which drive pathogenesis of these diseases. A...
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Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding the efforts of...
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GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma
BackgroundThe cure rate for metastatic osteosarcoma has not substantially improved over the past decades. Clinical trials of anti-HER2 trastuzumab or...
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Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infection
Interleukin-11 (IL-11), a well-known anti-inflammatory factor, provides protection from intestinal epithelium damage caused by physical or chemical...
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Cellular immunotherapy: a clinical state-of-the-art of a new paradigm for cancer treatment
Cancer immunotherapy has opened a new chapter in Medical Oncology. Many novel therapies are under clinical testing and some have already been...
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Expert consensus on the diagnosis and treatment of thrombocytopenia in adult critical care patients in China
Thrombocytopenia is a common complication of critical care patients. The rates of bleeding events and mortality are also significantly increased in...
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Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance
Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug...
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High-Throughput Approaches to the Development of Molecular Imaging Agents
Molecular imaging allows for the visualization of changes at the cellular level in diseases such as cancer. A successful molecular imaging agent must...
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Side Effects of Cytokines Approved for Therapy
Cytokines, currently known to be more than 130 in number, are small MW (<30 kDa) key signaling proteins that modulate cellular activities in...
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Tumor self-seeding by circulating tumor cells in nude mouse models of human osteosarcoma and a preliminary study of its mechanisms
PurposeThe purpose of this study is to determine whether and how tumor self-seeding by circulating tumor cells (CTCs) plays a role in the initiation...
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Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway
To evaluate the relationship between IL-11 and bone metastasis in patients with breast cancer and explore the potential molecular mechanism, total...
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Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: a possible diagnostic tool for impaired fertility
BackgroundUterine receptivity and implantation are complex processes requiring coordinated expression of molecules by zygote and uterus. Our...
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Dual-Labeling Strategies for Nuclear and Fluorescence Molecular Imaging: A Review and Analysis
Molecular imaging is used for the detection of biochemical processes through the development of target-specific contrast agents. Separately,...
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Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma
BackgroundInterleukin (IL) 11 is produced by human endometrium and endometrial cancer tissue. It has roles in endometrial epithelial cell adhesion...
