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Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren’s syndrome
We aim to assess and compare a cytokine and chemokine profile in tears from patients with IgG4-related disease (IgG4-RD) and Sjögren’s syndrome (SS),...
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Increased IL-1α expression in chronic rhinosinusitis with nasal polyps
PurposeTo examine whether and how interleukin (IL)-1α is involved in chronic rhinosinusitis with nasal polyps (CRSwNP).
MethodsNasal polyp (NP) and...
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IL-6 regulates epithelial ovarian cancer EMT, invasion, and metastasis by modulating Let-7c and miR-200c through the STAT3/HIF-1α pathway
Interleukin-6 (IL-6) and hypoxia-inducible factor-1α (HIF-1α) play important roles in epithelial-mesenchymal transformation (EMT) and tumor...
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Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy
IL-1α and IL-1β are both involved in several aspects of tumor biology, including tumor initiation, progression, metastasis, and not least in...
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Associations between IL-1α, IL-1β, TNFα, and IL-6 variations, and susceptibility to transposition of the great arteries
BackgroundTo evaluate the relationship between IL-1α -889C/T (rs1800587), IL-1β -511C > T (rs16944), TNFα -308G > A (rs1800629), TNFα -238G > A...
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Ubiquitination of ADRα1d/SerpinA1 complex stimulates hypoxia to induce gastric tumorigenesis with a combination of Helicobacter pylori and chronic stress through IL-1α
BackgroundHelicobacter pylori ( H. pylori ) has been recognized as the class I carcinogen of gastric cancer and several studies have demonstrated that...
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Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism
BackgroundObstructive sleep apnea (OSA) can be considered a chronic inflammatory disease that impacts all bodily systems, including the immune...
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HIF-1α facilitates glioma proliferation and invasion by activating pyroptosis signaling axis
BackgroundHIF-1α is thought to be a novel regulator which contributes to carcinogenesis. However, the mechanism underlying the effect of HIF-1α in...
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Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α, and CCL5 levels
There are only a few studies reporting on the immunological profiles of methamphetamine (MA) use, MA dependency, or MA-induced psychosis (MAP). This...
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SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
PurposeThe aim of this study was to elucidate the factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may...
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Exercise following joint distraction inhibits muscle wasting and delays the progression of post-traumatic osteoarthritis in rabbits by activating PGC-1α in skeletal muscle
ObjectiveMuscle wasting frequently occurs following joint trauma. Previous research has demonstrated that joint distraction in combination with...
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Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1α levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation
ObjectiveMedication overuse headache (MOH) was recently shown to be associated with leaky gut in rodents. We aimed to investigate whether chronic...
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Mitochondrial DNA is a key driver in cigarette smoke extract-induced IL-6 expression
Smoking is an independent risk factor for atherosclerosis, the primary pathogenesis of which is inflammation. We recently reported that cigarette...
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Safety of YAG laser vitreolysis for intraocular tissues: analysis of postoperative complications
PurposeTo evaluate the safety of yttrium–aluminum-garnet (YAG) laser vitreolysis for intraocular tissues.
MethodsThirty-six New Zealand rabbits were...
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Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1α- circCDC42BPB pathway
ObjectivesRheumatoid arthritis (RA) is a chronic inflammatory joint disease, which might trigger cartilage, bone damage, and disability. Recent...
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The prognostic role of HIF-1α and NF-κB expression in RAS wild-type metastatic colorectal cancer: A Turkish Oncology Group (TOG) study
BackgroundNot all RAS wild-type metastatic colorectal cancer (mCRC) patients experience the same benefit from anti-epidermal growth factor receptor...
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Efficacy of LL-37 cream in enhancing healing of diabetic foot ulcer: a randomized double-blind controlled trial
Wound healing in DFU (diabetic foot ulcer) has prolonged inflammation phase and defective granulation tissue formation. LL-37 has antimicrobial...
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Inflammatory profile in patients with rheumatoid arthritis and sarcopenia
IntroductionSarcopenia is characterized by the loss of muscle mass and strength associated with aging; however, individuals with chronic diseases are...
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RETRACTED ARTICLE: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and their association with the disease severity and activity
BackgroundThe epidemiology of Crohn’s disease (CD) has changed over the past decades, demonstrating a trend toward increased prevalence in develo**...
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Perinatal inflammation, fetal growth restriction, and long-term neurodevelopmental impairment in Bangladesh
BackgroundThere are limited data on the impact of perinatal inflammation on child neurodevelopment in low-middle income countries and among...
