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Confirming the association between low serum 25OHD levels in girls with central precocious puberty and its severity
BackgroundTo assess the differences in vitamin D levels in girls with rapidly progressive (RP) or slowly progressive (SP) central precocious puberty...
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Insulin-Like Growth Factor 1 Related to Chronic Low-Grade Inflammation in Patients with Obesity and Early Change of its Levels After Laparoscopic Sleeve Gastrectomy
BackgroundInsulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein (IGFBP) have an influence on metabolism. However,...
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Circ_0006640 transferred by bone marrow-mesenchymal stem cell-exosomes suppresses lipopolysaccharide-induced apoptotic, inflammatory and oxidative injury in spinal cord injury
BackgroundEmerging proofs have shown that differentially expressed circular RNAs (circRNAs) are closely associated with the pathophysiological...
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The effect of SGLT2i on the GH/IGF1 axis in newly diagnosed male T2D patients – a prospective, randomized case–control study
PurposeTo investigate the effect of SGLT2i on the GH/IGF1 axis in male patients with newly diagnosed type 2 diabetes (T2D).
MethodsSixty male...
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The spectrum of cardiac abnormalities in patients with acromegaly: results from a case-control cardiac magnetic resonance study
PurposeCardiac abnormalities are common in patients with acromegaly, contributing to the increased morbidity and mortality. Cardiac magnetic...
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Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy
ObjectiveThis study aimed to assess the long-term outcome of patients with acromegaly.
DesignThis is a multicenter, retrospective, observational...
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Relationship between 25-hydroxyvitamin D and IGF1: a cross-sectional study of the Third National Health and Nutrition Examination Survey participants
Background25-Hydroxyvitamin D (25OHD) and insulin-like growth factor 1 (IGF1) are crucial for bone health. Some studies have shown that they...
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Role of specific nutritional biomarkers in predicting post-operative complications among patients undergoing elective abdominal surgery
PurposeNutritional biomarkers like serum prealbumin, transferrin, retinol-binding protein (RBP), C-reactive protein (CRP), leptin, and insulin-like...
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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and...
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Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma
BackgroundAsthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with...
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Autonomous growth hormone secretion due to McCune Albright syndrome in paediatric age group: an ominous triad
PurposeThe current study aimed to report cases of McCune Albright syndrome (MAS) with growth hormone (GH) hyper secretion along with a systematic...
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Exercise Promotes Tissue Regeneration: Mechanisms Involved and Therapeutic Scope
Exercise has well-recognized beneficial effects on the whole body. Previous studies suggest that exercise could promote tissue regeneration and...
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Insulin-like growth factor 1 receptor inhibits the proliferation of acute myeloid leukaemia cells via NK cell activation
Acute myeloid leukaemia (AML) denotes a heterogeneous category of cancers occurring within the bone marrow that are initiated by the unrestricted...
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Correlation analysis between polymorphism of leptin and IGFI genes and body measurements in Barki and Farafra sheep
BackgroundGrowth performance, which can be evaluated using various body measurements, is crucial for providing red meat for human consumption. This...
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Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a hematological malignancy derived from the accumulation of abnormal proliferation of infantile leukocytes...
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Transcriptome and single-cell transcriptomics reveal prognostic value and potential mechanism of anoikis in skin cutaneous melanoma
BackgroundSkin cutaneous melanoma (SKCM) is a highly lethal cancer, ranking among the top four deadliest cancers. This underscores the urgent need...
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Stem Cell Transcription Factor Sox2 Is Expressed in a Subset of Folliculo-stellate Cells of Growth Hormone–Producing Pituitary Neuroendocrine Tumours and Its Expression Shows No Association with Tumour Size or IGF1 Levels: a Clinicopathological Study of 109 Cases
Sox2 is one of the transcription factors responsible for the maintenance of stem cell phenotype. It has been implicated as a marker of stem cells in...
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Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory
Aims/hypothesisThere is a growing need for markers that could help indicate the decline in beta cell function and recognise the need and efficacy of...
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Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1
The development and maturation of ovarian follicles is a complex and highly regulated process, which is essential for successful ovulation. During...
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Possible genetic cross-talk between Down syndrome and obstructive sleep apnea revealed by transcriptomic analysis
PurposeDown syndrome (DS) is linked to a higher prevalence of obstructive sleep apnea (OSA) than in the general population, which in turn contributes...
