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The role of IGF/IGF-1R signaling in the regulation of cancer stem cells
Cancer stem cells (CSCs) are a group of tumor cells with high tumorigenic ability and self-renewal potential similar to those of normal stem...
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CBX1 is involved in hepatocellular carcinoma progression and resistance to sorafenib and lenvatinib via IGF-1R/AKT/SNAIL signaling pathway
BackgroundChromobox Homolog 1 (CBX1) plays a crucial role in the pathogenesis of numerous diseases, including the evolution and advancement of...
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Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease
ObjectiveDiabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to...
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Role of IGF-1R in epithelial–mesenchymal transdifferentiation of human peritoneal mesothelial cells
BackgroundPeritoneal fibrosis (PF) is caused by epithelial-mesenchymal transdifferentiation (EMT) in the peritoneum under high glucose (HG)...
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IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma
As the p53 tumor suppressor is rarely mutated in conjunctival melanoma (CM), we investigated its activation as a potential therapeutic strategy....
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IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas
The insulin-like growth factor 1 receptor (IGF-1R) governs several signaling pathways for cell proliferation, survival, and anti-apoptosis. Thus,...
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IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits
Mature type 1 insulin-like growth factor receptors (IGF-1Rs) are heterotetrameric structures comprising two extracellular α-subunits...
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CHK1 inhibition exacerbates replication stress induced by IGF blockade
We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces...
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DDAB cationic lipid-mPEG, PCL copolymer hybrid nano-carrier synthesis and application for delivery of siRNA targeting IGF-1R into breast cancer cells
Background and objectiveTo use siRNA molecule as a therapeutic agent in gene silencing, an efficient delivery system is necessary. Stability and...
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Crucial role of androgen receptor in resistance and endurance trainings-induced muscle hypertrophy through IGF-1/IGF-1R- PI3K/Akt- mTOR pathway
BackgroundAndrogen receptor (AR) has been reported to play vital roles in exercise-induced increase of muscle mass in rats, but needs to be further...
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Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines
The beneficial effects of lipoic acid (LA) in cancer treatment have been well documented in the last decade. Indeed, LA exerts crucial...
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Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability
PurposeMeningioma is the most common primary central nervous system tumor often causing serious complications, and presently no medical treatment is...
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Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents
Ewing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation ( EWSR1::FLI1 ) leads to a...
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Insulin-Like Growth Factor 1 Receptor Drives Hepatocellular Carcinoma Growth and Invasion by Activating Stat3-Midkine-Stat3 Loop
BackgroundActivation of the insulin-like growth factor 1 receptor (IGF-1R)-mediated Janus kinase (JAK)1/2-Stat3 pathway contributes to...
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Androgen receptor regulates the proliferation of myoblasts under appropriate or excessive stretch through IGF-1 receptor mediated p38 and ERK1/2 pathways
BackgroundAndrogen receptor (AR) exerts important roles in exercise-induced alterations of muscle mass, in which the proliferation and...
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Histological transformation to gliosarcoma with combined BRAF/MEK inhibition in BRAF V600E mutated glioblastoma
The identification of BRAF V600 mutation in multiple cancers beyond melanoma and the development of combined BRAF and MEK targeting agents have...
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Activation of IGF-1R pathway and NPM-ALK G1269A mutation confer resistance to crizotinib treatment in NPM-ALK positive lymphoma
ALK-positive anaplastic large cell lymphoma (ALCL) represents a subset of non-Hodgkin’s lymphoma that is treated with crizotinib, a dual ALK/MET...
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Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model
BackgroundEpileptic seizure is a process of energy accumulation, bursting, and depletion accompanied by the production, spread, and termination of...
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Effect of silencing C-erbB-2 on esophageal carcinoma cell biological behaviors by inhibiting IGF-1 pathway activation
ObjectiveC-erbB-2 has been confirmed to be an oncogene that participates in cell growth, differentiation and division of tumors. We are wondered if...
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STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis
Patients with advanced anaplastic lymphoma kinase ( ALK )-rearranged non-small cell lung cancer who are prescribed ALK-tyrosine kinase inhibitors...
